BioPolymers, Automated Cellular Infrastructure, Flow, and Integrated Chemistry Materials Innovation Platform (BioPACIFIC MIP)

The NSF BioPACIFIC MIP (DMR-1933487) merges advances in synthetic biology and synthetic chemistry by providing access to scientific expertise, multiscale computation and simulation for materials design, and advanced instrumentation capabilities to enable data-driven discovery and scalable production of bio-derived building blocks and polymers from yeast, fungi and bacteria, and the conversion of these blocks into next-generation polymers with properties and performance far exceeding those currently available in materials produced through traditional petrochemical-based methods.

BioPACIFIC MIP operates a one of a kind user facility dedicated to creating a nexus for synthetic biology and materials. Users are uniquely able to elucidate biomaterial structure and function to achieve materials-by-design, construct new bio-derived functional monomers from living organisms, access novel sequence-specific materials (e.g. peptoids), synthesize stimuli-responsive “smart” biomaterials, scale-up biomaterial production, and incorporate state-of-the-art field-theoretic simulation and machine learning algorithms.

In all cases, this platform is made possible by the unique and collective expertise of the BioPACIFIC MIP faculty and staff. BioPACIFIC MIP facilities are open to all US scientists via a peer-reviewed User Proposal process.

Publications

  • L. Zhao, H. Liu, B. K. Mai, Y. Zhang, L. Cheng, P. Liu, and Y. Yang
    Nonheme Fe 1,3-nitrogen migratases for asymmetric noncanonical amino acid synthesis
    Nature Chemical Biology
    (2025)
    10.1038/s41589-025-01953-w
  • J. Edmund, K. M. Karnaukh, S. Xie, E. A. Murphy, A. Abdilla, E. Ino, J. Read de Alaniz, C. J. Hawker, and R. A. Segalman
    Compatibilization of Immiscible Polymer Blends through Pendant Ionic Interactions
    Macromolecules
    (2025)
    10.1021/acs.macromol.5c00274
  • H. Wakidi, I. Lapkriengkri, A. Zele, S. Do, S. Arunlimsawat, A. Rhode, E. Lanuza, G. Rodriguez, V. Promarak, T. Nguyen‐Dang, A. A. Pitenis, C. M. Bates, M. L. Chabinyc, and T. Nguyen
    Photophysical and Viscoelastic Properties of Ionically Complexed Conjugated Polyelectrolyte for Printed Soft Electronics
    Advanced Functional Materials
    (2025)
    10.1002/adfm.202504946
  • F. Wong, A. Li, S. Omori, R. S. Lach, J. Nunez, Y. Ren, S. P. Brown, V. Singhal, B. R. Lyda, T. Batjargal, E. Dickson, J. R. Rodrigues Reyes, J. M. Uruena Vargas, S. Wahane, H. Kim, J. J. Collins, and M. Z. Wilson
    Optogenetics-enabled discovery of integrated stress response modulators
    Cell
    (2025)
    10.1016/j.cell.2025.06.024
  • C. Balzer, P. Springintveld, and G. H. Fredrickson
    Phase Behavior of Reversibly Bonding Polymer Blends
    Macromolecules
    (2025)
    10.1021/acs.macromol.5c01173
  • K. A. Konieczny, R. Rai, L. Palatinus, and M. A. Garcia-Garibay
    Topochemical Synthesis, micro-Electron Diffraction (3D ED), and Electron Beam-Initiated Topotactic Dimer Splitting of cis,syn-Thymine Dimer Crystals
    Journal of the American Chemical Society
    (2025)
    10.1021/jacs.5c02209
  • P. E. Jankoski, Z. M. Wallace, L. R. DiMartino, J. Shrestha, A. M. Davis, I. Owolabi, A. S. Flynt, and T. D. Clemons
    Combating Reactive Oxygen Species (ROS) with Antioxidant Supramolecular Polymers
    ACS Applied Materials & Interfaces
    (2025)
    10.1021/acsami.5c06967
  • P. Salas-Ambrosio, S. Vexler, R. P Sivasankaran, N. Vlahakis, R. S. Lai, C. Johnson, S. I. Baas-Maynard, D. S. Min, H. Lower, A. G. Doyle, Y. Tang, J. A. Rodriguez, I. A. Chen, J. Read de Alaniz, and H. D. Maynard
    Biosourced Functional Hydroxybenzoate-co-Lactide Polymers with Antimicrobial Activity
    Journal of the American Chemical Society
    147
    19230-19238
    (2025)
    10.1021/jacs.5c04624
  • M. J. Ford, R. Telles, D. H. Porcincula, C. G. Reyes, S. Paul, I. Hendrix, E. Hawkes, J. Read de Alaniz, C. C. Cook, and E. Lee
    Versatile Liquid Crystal Elastomer Formulations Using Amine-Acrylate Chemistry and Processing for Advanced Manufacturing
    ACS Applied Engineering Materials
    3
    1389-1398
    (2025)
    10.1021/acsaenm.5c00176
  • E. Davoodi, J. Li, X. Ma, A. H. Najafabadi, J. Yoo, G. Lu, E. S. Sani, S. Lee, H. Montazerian, G. Kim, J. Williams, J. W. Yang, Y. Zeng, L. S. Li, Z. Jin, B. Sadri, S. S. Nia, L. V. Wang, T. K. Hsiai, P. S. Weiss, Q. Zhou, A. Khademhosseini, D. Wu, M. G. Shapiro, and W. Gao
    Imaging-guided deep tissue in vivo sound printing
    Science
    388
    616-623
    (2025)
    10.1126/science.adt0293
  • A. J. Macbeth, D. Markovich, A. L. Taylor, E. B. Flanagan, J. E. Borowski, J. H. Hsu, C. R. Peltier, D. A. Muller, B. P. Fors, K. J. T. Noonan, and G. W. Coates
    Designing Highly Conductive Anion Exchange Membranes: Tuning Domain Continuity with ABC Block Copolymer Self-Assembly
    Journal of the American Chemical Society
    147
    16471-16480
    (2025)
    10.1021/jacs.5c03175
  • H. Senebandith, F. Albreiki, P. A. Kohl, A. Odenheimer, K. C. Pyone, Y. Li, and S. Srivastava
    Microstructural Rearrangements in Triblock Polyelectrolyte Complex Hydrogels
    ACS Macro Letters
    14
    544-550
    (2025)
    10.1021/acsmacrolett.5c00029
  • A. Saha, M. Mecklenburg, A. J. Pattison, A. S. Brewster, J. A. Rodriguez, and P. Ercius
    Imaging the Progression of Radiolytic Damage in Molecular Crystals with Scanning Nanobeam Electron Diffraction
    Physical Review Letters
    134
    (2025)
    10.1103/physrevlett.134.146101
  • J. Huang, J. Chen, and Y. Luo
    Cell‐Sheet Shape Transformation by Internally‐Driven, Oriented Forces
    Advanced Materials
    37
    (2025)
    10.1002/adma.202416624
  • W. Fu, K. Murcek, J. Chen, A. Liu, Y. Zhao, P. Liu, and Y. Yang
    Catalytic Enantioselective Smiles Rearrangement Enabled by the Directed Evolution of P450 Radical Aryl Migratases
    Journal of the American Chemical Society
    147
    12197-12205
    (2025)
    10.1021/jacs.5c01179
  • Y. Kwon, Y. Tang, C. D. Eisenbach, and M. T. Valentine
    Latent Thermal Transformation of 3D-Printed Polymer Composite Foams Provides Tailored Mechanical Properties
    ACS Applied Polymer Materials
    7
    4142-4152
    (2025)
    10.1021/acsapm.4c03740
  • K. Buaksuntear, P. Kohl, Y. Li, and W. Smitthipong
    Improvement of Carbon Black Dispersion in Mussel-Inspired Composites from Epoxidized Natural Rubber Using Aromatic Interactions
    ACS Applied Polymer Materials
    7
    3576-3587
    (2025)
    10.1021/acsapm.4c03648
  • N. Vlahakis, A. Clauss, and J. A. Rodriguez
    Accounting for electron-beam-induced warping of molecular nanocrystals in MicroED structure determination
    IUCrJ
    12
    223-238
    (2025)
    10.1107/s2052252524012132
  • X. Fang, E. A. Murphy, P. A. Kohl, Y. Li, C. J. Hawker, C. M. Bates, and M. Gu
    Universal Phase Identification of Block Copolymers From Physics‐Informed Machine Learning
    Journal of Polymer Science
    63
    1433-1440
    (2025)
    10.1002/pol.20241063
  • Y. Yuan, S. Beilharz, H. R. Everson, N. Nupnar, M. K. Debnath, D. Vinella, J. M. Urueña, F. H. Örge, M. J. A. Hore, D. Mathur, and M. Karayilan
    Injectable Fluorescent Bottlebrush Polymers for Interventional Procedures and Biomedical Imaging
    Biomacromolecules
    26
    1234-1250
    (2025)
    10.1021/acs.biomac.4c01550
  • Y. Okayama, P. Morris, K. Albanese, S. Olsen, A. Mori, J. R. de Alaniz, C. M. Bates, and C. J. Hawker
    Enhanced Degradation of Vinyl Copolymers Based on Lipoic Acid
    Journal of Polymer Science
    63
    1345-1351
    (2025)
    10.1002/pol.20241085
  • S. Cui, E. A. Murphy, S. Santra, F. S. Bates, and T. P. Lodge
    Mesoscopic Morphologies in Frustrated ABC Bottlebrush Block Terpolymers
    ACS Nano
    19
    1211-1221
    (2025)
    10.1021/acsnano.4c13416
  • E. C. McGarrigle, H. D. Ceniceros, and G. H. Fredrickson
    Projected complex Langevin sampling method for bosons in the canonical and microcanonical ensembles
    Physical Review E
    110
    (2024)
    10.1103/physreve.110.065308
  • T. Kolozsvary, P. Kohl, T. Li, D. Gillespie, Y. Li, and B. R. McDonald
    The Precise Synthesis of Ultradense Bottlebrush Polymers Unearths Unique Trends in Lyotropic Ordering
    Journal of the American Chemical Society
    147
    889-897
    (2024)
    10.1021/jacs.4c13759
  • Y. Tang, M. Levin, O. G. Long, C. D. Eisenbach, N. Cohen, and M. T. Valentine
    Data-Driven Framework for the Prediction of PEGDA Hydrogel Mechanics
    ACS Biomaterials Science & Engineering
    11
    259-267
    (2024)
    10.1021/acsbiomaterials.4c01762
  • M. Czuczola, M. S. Hossain, D. P. Shannon, P. T. Morris, P. T. Getty, C. M. Bates, J. Read de Alaniz, and C. J. Hawker
    Telechelic Dithiol Copolymers as Tunable Building Blocks for Synthesizing Multiblock Materials
    Journal of Polymer Science
    63
    759-765
    (2024)
    10.1002/pol.20240876
  • D. P. Shannon, K. Cerdan, M. Kim, M. Mecklenburg, J. Su, Y. Chen, M. E. Helgeson, M. T. Valentine, and C. J. Hawker
    Bioinspired Metal–Ligand Networks with Enhanced Stability and Performance: Facile Preparation of Hydroxypyridinone (HOPO)-Functionalized Materials
    Macromolecules
    57
    11339-11349
    (2024)
    10.1021/acs.macromol.4c02250
  • K. A. Konieczny, I. Paul, J. A. Rodriguez, and M. A. Garcia-Garibay
    From Beam Damage to Massive Reaction Amplification under the Electron Microscope: An Ionization-Induced Chain Reaction in Crystals of a Dewar Benzene
    ACS Central Science
    10
    2346-2352
    (2024)
    10.1021/acscentsci.4c01429
  • P. H. Nguyen, D. Callan, E. Plunkett, M. Gruschka, N. Alizadeh, M. R. Landsman, G. M. Su, E. Gann, C. M. Bates, D. M. DeLongchamp, and M. L. Chabinyc
    Resonant Soft X-ray Scattering Reveals the Distribution of Dopants in Semicrystalline Conjugated Polymers
    The Journal of Physical Chemistry B
    128
    12597-12611
    (2024)
    10.1021/acs.jpcb.4c05774
  • I. Arias Ponce, R. Sujanani, J. D. Moon, J. M. Urueña, C. J. Hawker, and R. A. Segalman
    3D Printing of Functional Hydrogel Devices for Screenings of Membrane Permeability and Selectivity
    ACS Applied Polymer Materials
    6
    14629-14637
    (2024)
    10.1021/acsapm.4c02732
  • Y. Wang, X. Tan, Y. Zhang, D. J. T. Hill, A. Zhang, D. Kong, C. J. Hawker, A. K. Whittaker, and C. Zhang
    Discrete Side Chains for Direct Tuning Properties of Grafted Polymers
    Macromolecules
    57
    11753-11762
    (2024)
    10.1021/acs.macromol.4c02533
  • K. Watanabe, D. Chen, Y. Zhu, D. Callan, G. H. Fredrickson, and C. M. Bates
    Stability of Frank–Kasper Phases in ABn Miktoarm Star Polymers with Dispersity in n: Simulations and Experiments
    Macromolecules
    57
    11289-11295
    (2024)
    10.1021/acs.macromol.4c02202
  • M. Xu, B. Huang, H. K. Beech, P. T. Getty, J. M. Urueña, and C. J. Hawker
    Efficient Cross-Linking through C–H Bond Insertion of Unfunctionalized Commodity Materials Using Diazirine-Containing Polymers
    ACS Macro Letters
    13
    1598-1604
    (2024)
    10.1021/acsmacrolett.4c00675
  • L. P. Dow, S. Surace, K. Morozov, R. Kennedy, and B. L. Pruitt
    Cyclic stretch regulates epithelial cell migration in a frequency dependent manner via intercellular vinculin recruitment
    npj Biological Physics and Mechanics
    1
    (2024)
    10.1038/s44341-024-00003-1
  • X. Yuan, D. Cheng, B. Liu, K. Liang, K. Liang, J. Yu, M. Mecklenburg, P. Sautet, and Y. Li
    Engineering battery corrosion films by tuning electrical double layer composition
    Joule
    8
    3038-3053
    (2024)
    10.1016/j.joule.2024.07.011
  • P. T. Morris, K. Watanabe, K. R. Albanese, G. T. Kent, R. Gupta, M. Gerst, J. Read de Alaniz, C. J. Hawker, and C. M. Bates
    Scalable Synthesis of Degradable Copolymers Containing α-Lipoic Acid via Miniemulsion Polymerization
    Journal of the American Chemical Society
    146
    30662-30667
    (2024)
    10.1021/jacs.4c12438
  • S. Han, V. A. Bobrin, M. Michelas, C. J. Hawker, and C. Boyer
    Sustainable and Recyclable Acrylate Resins for Liquid-Crystal Display 3D Printing Based on Lipoic Acid
    ACS Macro Letters
    13
    1495-1502
    (2024)
    10.1021/acsmacrolett.4c00600
  • E. C. McGarrigle, R. Nodel, K. T. Delaney, L. Balents, and G. H. Fredrickson
    Thermodynamic stability of a spin microemulsion in Rashba spin-orbit-coupled bosons
    Physical Review A
    110
    (2024)
    10.1103/physreva.110.l041303
  • C. Li, E. A. Murphy, S. J. Skala, K. T. Delaney, C. J. Hawker, M. S. Shell, and G. H. Fredrickson
    Accelerated Prediction of Phase Behavior for Block Copolymer Libraries Using a Molecularly Informed Field Theory
    Journal of the American Chemical Society
    146
    29751-29758
    (2024)
    10.1021/jacs.4c11258
  • A. Datta, X. Wang, S. D. Mengel, A. J. DeStefano, R. A. Segalman, P. T. Underhill, and M. E. Helgeson
    A Gram–Charlier Analysis of Scattering to Describe Nonideal Polymer Conformations
    Macromolecules
    57
    9518-9535
    (2024)
    10.1021/acs.macromol.4c01169
  • D. Chen, M. A. Klatt, and G. H. Fredrickson
    Emergence of Disordered Hyperuniformity in Melts of Linear Diblock Copolymers
    Macromolecules
    57
    9911-9919
    (2024)
    10.1021/acs.macromol.4c01807
  • D. Vinciguerra, J. Yang, P. G. Georgiou, K. Snell, T. Pesenti, J. Collins, M. Tamboline, S. Xu, R. M. van Dam, K. M. M. Messina, A. L. Hevener, and H. D. Maynard
    A Glucose-Responsive Glucagon-Micelle for the Prevention of Hypoglycemia
    ACS Central Science
    10
    2036-2047
    (2024)
    10.1021/acscentsci.4c00937
  • A. R. Rhode, I. Montes de Oca, M. L. Chabinyc, C. M. Bates, and A. A. Pitenis
    Sliding on Slide-Ring Gels
    Tribology Letters
    72
    (2024)
    10.1007/s11249-024-01920-x
  • A. Julbust, K. Buaksuntear, S. Suethao, P. Kohl, Y. Li, and W. Smitthipong
    Crosslinked Natural Rubber and Styrene Butadiene Rubber Blends/Carbon Black Composites for Self-healable and Energy-saved Applications
    Chinese Journal of Polymer Science
    42
    1835-1844
    (2024)
    10.1007/s10118-024-3208-3
  • M. Gu, Y. He, X. Liu, and Y. Luo
    Ab initio uncertainty quantification in scattering analysis of microscopy
    Physical Review E
    110
    (2024)
    10.1103/physreve.110.034601
  • T. Huang, R. Levenson, Y. Li, P. Kohl, D. E. Morse, M. S. Shell, and M. E. Helgeson
    A colloidal model for the equilibrium assembly and liquid-liquid phase separation of the reflectin A1 protein
    Biophysical Journal
    123
    3065-3079
    (2024)
    10.1016/j.bpj.2024.07.004
  • W. Fu, Y. Fu, Y. Zhao, H. Wang, P. Liu, and Y. Yang
    A metalloenzyme platform for catalytic asymmetric radical dearomatization
    Nature Chemistry
    16
    1999-2008
    (2024)
    10.1038/s41557-024-01608-8
  • M. V. T. Nguyen, N. Sherck, S. Köhler, E. Schreiner, R. Gupta, G. H. Fredrickson, and M. S. Shell
    Multiscale Computational Study of Cellulose Acetate–Water Miscibility: Insights from Molecularly Informed Field-Theoretic Modeling
    Biomacromolecules
    25
    5809-5818
    (2024)
    10.1021/acs.biomac.4c00474
  • C. Balzer, and G. H. Fredrickson
    Sequence and gelation in supramolecular polymers
    The Journal of Chemical Physics
    161
    (2024)
    10.1063/5.0218748
  • K. Ding, M. Chin, Y. Zhao, W. Huang, B. K. Mai, H. Wang, P. Liu, Y. Yang, and Y. Luo
    Machine learning-guided co-optimization of fitness and diversity facilitates combinatorial library design in enzyme engineering
    Nature Communications
    15
    (2024)
    10.1038/s41467-024-50698-y
  • T. M. Tran, and J. Read de Alaniz
    Synthesis and Thermo-Selective Recycling of Diels–Alder Cyclopentadiene Thermoplastics
    Journal of the American Chemical Society
    146
    20972-20981
    (2024)
    10.1021/jacs.4c05952
  • E. M. Novikov, J. Guillen Campos, J. Read de Alaniz, M. S. Fonari, and T. V. Timofeeva
    Synthesis, molecular and crystal structures of 4-amino-3,5-difluorobenzonitrile, ethyl 4-amino-3,5-difluorobenzoate, and diethyl 4,4′-(diazene-1,2-diyl)bis(3,5-difluorobenzoate)
    Acta Crystallographica Section E Crystallographic Communications
    80
    867-872
    (2024)
    10.1107/s2056989024006819
  • M. Levin, Y. Tang, C. D. Eisenbach, M. T. Valentine, and N. Cohen
    Understanding the Response of Poly(ethylene glycol) diacrylate (PEGDA) Hydrogel Networks: A Statistical Mechanics-Based Framework
    Macromolecules
    57
    7074-7086
    (2024)
    10.1021/acs.macromol.3c02635
  • M. Roguski, M. L. Davidson, A. J. DeStefano, R. A. Segalman, and L. M. Walker
    Polypeptoid Monomer Sequence and Chemical Composition as Independent Controls of Interfacial Tension and Elasticity at Air/Fluid Interfaces
    Langmuir
    40
    15353-15362
    (2024)
    10.1021/acs.langmuir.4c02195
  • S. D. Mengel, A. J. DeStefano, T. Webber, A. Semerdjiev, S. Han, and R. A. Segalman
    Salt-Screened Transition toward Bulk-Like Water Dynamics near Polymeric Zwitterions
    ACS Macro Letters
    13
    928-934
    (2024)
    10.1021/acsmacrolett.4c00347
  • J. Cho, A. Saha, and M. Mecklenburg
    Imaging by Diffraction in Transmission Electron Microscopy
    Microscopy and Microanalysis
    30
    (2024)
    10.1093/mam/ozae044.148
  • X. Yuan, M. Mecklenburg, and Y. Li
    Spatially Resolved Components in Battery Corrosion Films by 4D STEM
    Microscopy and Microanalysis
    30
    (2024)
    10.1093/mam/ozae044.935
  • K. R. Albanese, P. T. Morris, B. Roehrich, J. Read de Alaniz, C. J. Hawker, and C. M. Bates
    Selective electrochemical degradation of bottlebrush elastomers
    Journal of Polymer Science
    62
    4326-4331
    (2024)
    10.1002/pol.20240393
  • M. Mecklenburg, S. S. Nia, A. Saha, and Z. Hong Zhou
    Paths to Attenuate Radiolysis-Induced Secondary Damage in Biological CryoEM
    Microscopy and Microanalysis
    30
    (2024)
    10.1093/mam/ozae044.877
  • H. Alimohamadi, E. W. Luo, S. Gupta, J. de Anda, R. Yang, T. Mandal, and G. C. L. Wong
    Comparing Multifunctional Viral and Eukaryotic Proteins for Generating Scission Necks in Membranes
    ACS Nano
    18
    15545-15556
    (2024)
    10.1021/acsnano.4c00277
  • C. A. D’Ambra, P. T. Getty, T. Eom, M. Czuczola, E. A. Murphy, S. Biswas, A. Abdilla, J. M. Mecca, T. D. Bekemeier, S. Swier, A. Fielitz, C. J. Hawker, and C. M. Bates
    Facile Preparation of Tunable Polyborosiloxane Networks via Hydrosilylation
    Chemistry of Materials
    36
    5935-5942
    (2024)
    10.1021/acs.chemmater.4c00224
  • K. R. Albanese, J. Read de Alaniz, C. J. Hawker, and C. M. Bates
    From health supplement to versatile monomer: Radical ring-opening polymerization and depolymerization of α-lipoic acid
    Polymer
    304
    127167
    (2024)
    10.1016/j.polymer.2024.127167
  • K. Luong, and A. Singh
    Application of Transformers in Cheminformatics
    Journal of Chemical Information and Modeling
    64
    4392-4409
    (2024)
    10.1021/acs.jcim.3c02070
  • G. E. Kunkel, Q. Zhou, J. W. Treacy, H. R. Montgomery, P. Salas-Ambrosio, A. D. Ready, A. M. Spokoyny, K. N. Houk, and H. D. Maynard
    Comparison of Cyclic and Linear PEG Conjugates
    Bioconjugate Chemistry
    35
    744-749
    (2024)
    10.1021/acs.bioconjchem.4c00202
  • T. Wang, B. K. Mai, Z. Zhang, Z. Bo, J. Li, P. Liu, and Y. Yang
    Stereoselective amino acid synthesis by photobiocatalytic oxidative coupling
    Nature
    629
    98-104
    (2024)
    10.1038/s41586-024-07284-5
  • A. Al Kindi, N. S. Courelli, K. Ogbonna, J. M. Urueña, A. L. Chau, and A. A. Pitenis
    Bioinspired Lubricity from Surface Gel Layers
    Langmuir
    40
    9926-9933
    (2024)
    10.1021/acs.langmuir.3c03686
  • L. Zhao, B. K. Mai, L. Cheng, F. Gao, Y. Zhao, R. Guo, H. Wu, Y. Zhang, P. Liu, and Y. Yang
    Biocatalytic enantioselective C(sp3)–H fluorination enabled by directed evolution of non-haem iron enzymes
    Nature Synthesis
    3
    967-975
    (2024)
    10.1038/s44160-024-00536-2
  • A. R. Talosig, F. Wang, J. T. Mulvey, B. P. Carpenter, E. M. Olivas, B. B. Katz, C. Zhu, and J. P. Patterson
    Understanding the Nucleation and Growth of ZIF-8 Polymorphs
    Crystal Growth & Design
    24
    4136-4142
    (2024)
    10.1021/acs.cgd.4c00194
  • S. Ju, D. Li, B. K. Mai, X. Liu, A. Vallota-Eastman, J. Wu, D. L. Valentine, P. Liu, and Y. Yang
    Stereodivergent photobiocatalytic radical cyclization through the repurposing and directed evolution of fatty acid photodecarboxylases
    Nature Chemistry
    16
    1339-1347
    (2024)
    10.1038/s41557-024-01494-0
  • C. W. Johnson, M. Ohashi, and Y. Tang
    How Fungi Biosynthesize 3-Nitropropanoic Acid: The Simplest yet Lethal Mycotoxin
    Organic Letters
    26
    3158-3163
    (2024)
    10.1021/acs.orglett.4c00758
  • K. Yang, D. M. Rivera Mirabal, R. V. Garcia, N. W. Vlahakis, P. H. Nguyen, S. D. Mengel, M. Mecklenburg, J. A. Rodriguez, M. S. Shell, C. J. Hawker, and R. A. Segalman
    Crystallization-Induced Flower-like Superstructures via Peptoid Helix Assembly
    ACS Macro Letters
    13
    423-428
    (2024)
    10.1021/acsmacrolett.4c00039
  • E. A. Murphy, C. Zhang, C. M. Bates, and C. J. Hawker
    Chromatographic Separation: A Versatile Strategy to Prepare Discrete and Well-Defined Polymer Libraries
    Accounts of Chemical Research
    57
    1202-1213
    (2024)
    10.1021/acs.accounts.4c00059
  • J. Chen, V. Bhat, and C. J. Hawker
    High-Throughput Synthesis, Purification, and Application of Alkyne-Functionalized Discrete Oligomers
    Journal of the American Chemical Society
    146
    8650-8658
    (2024)
    10.1021/jacs.4c00751
  • D. J. Atkins, J. M. Rosas, L. K. Månsson, N. Shahverdi, S. S. Dey, and A. A. Pitenis
    Survival-Associated Cellular Response Maintained in Pancreatic Ductal Adenocarcinoma (PDAC) Switched Between Soft and Stiff 3D Microgel Culture
    ACS Biomaterials Science & Engineering
    10
    2177-2187
    (2024)
    10.1021/acsbiomaterials.3c01079
  • S. Cui, E. A. Murphy, W. Zhang, A. Zografos, L. Shen, F. S. Bates, and T. P. Lodge
    Cylinders-in-Undulating-Lamellae Morphology from ABC Bottlebrush Block Terpolymers
    Journal of the American Chemical Society
    146
    6796-6805
    (2024)
    10.1021/jacs.3c13543
  • T. Göckler, F. Albreiki, D. Li, A. Grimm, F. Mecklenburg, J. M. Urueña, U. Schepers, and S. Srivastava
    Block Polyelectrolyte Additives That Modulate the Viscoelasticity and Enhance the Printability of Gelatin Inks at Physiological Temperatures
    ACS Applied Polymer Materials
    6
    2427-2441
    (2024)
    10.1021/acsapm.3c01085
  • A. J. DeStefano, S. D. Mengel, M. W. Bates, S. Jiao, M. S. Shell, S. Han, and R. A. Segalman
    Control over Conformational Landscapes of Polypeptoids by Monomer Sequence Patterning
    Macromolecules
    57
    1469-1477
    (2024)
    10.1021/acs.macromol.3c02338
  • E. A. Murphy, S. J. Skala, D. Kottage, P. A. Kohl, Y. Li, C. Zhang, C. J. Hawker, and C. M. Bates
    Accelerated discovery and mapping of block copolymer phase diagrams
    Physical Review Materials
    8
    (2024)
    10.1103/physrevmaterials.8.015602
  • C. W. Barney, S. Berezvai, A. L. Chau, Y. Kwon, A. A. Pitenis, R. M. McMeeking, M. T. Valentine, and M. E. Helgeson
    Experimental observation of near-wall effects during the puncture of soft solids
    Soft Matter
    20
    3806-3813
    (2024)
    10.1039/d3sm01216f
  • A. Holkar, S. Gao, K. Villaseñor, M. Lake, and S. Srivastava
    Quantitative turbidimetric characterization of stabilized complex coacervate dispersions
    Soft Matter
    20
    5060-5070
    (2024)
    10.1039/d3sm01761c
  • P. Salas-Ambrosio, C. I. Gupit, J. M. Urueña, Y. Luo, J. M. Hankett, R. Gupta, M. T. Valentine, H. D. Maynard, and M. E. Helgeson
    Evaluating polymerization kinetics using microrheology
    Polymer Chemistry
    15
    1758-1766
    (2024)
    10.1039/d4py00188e
  • M. V. T. Nguyen, K. Dolph, K. T. Delaney, K. Shen, N. Sherck, S. Köhler, R. Gupta, M. B. Francis, M. S. Shell, and G. H. Fredrickson
    Molecularly informed field theory for estimating critical micelle concentrations of intrinsically disordered protein surfactants
    The Journal of Chemical Physics
    159
    (2023)
    10.1063/5.0178910
  • M. J. Dror, J. Misa, D. A. Yee, A. M. Chu, R. K. Yu, B. B. Chan, L. S. Aoyama, A. P. Chaparala, S. E. O'Connor, and Y. Tang
    Engineered biosynthesis of plant heteroyohimbine and corynantheine alkaloids in Saccharomyces cerevisiae
    Journal of Industrial Microbiology and Biotechnology
    51
    (2023)
    10.1093/jimb/kuad047
  • Y. Okayama, T. Eom, M. Czuczola, A. Abdilla, J. R. Blankenship, K. R. Albanese, J. R. de Alaniz, C. M. Bates, and C. J. Hawker
    Heterotelechelic Silicones: Facile Synthesis and Functionalization Using Silane-Based Initiators
    Macromolecules
    56
    8806-8812
    (2023)
    10.1021/acs.macromol.3c01802
  • H. P. Truong, S. Mengel, B. Yu, R. A. Segalman, and O. A. Saleh
    Single-Molecule Polypeptoid Stretching Reveals the Effects of Charge Sequence on Chain Conformation
    Macromolecules
    56
    8558-8564
    (2023)
    10.1021/acs.macromol.3c01221
  • E. C. McGarrigle, K. T. Delaney, L. Balents, and G. H. Fredrickson
    Emergence of a Spin Microemulsion in Spin-Orbit Coupled Bose-Einstein Condensates
    Physical Review Letters
    131
    (2023)
    10.1103/physrevlett.131.173403
  • S. J. Bailey, E. Hopkins, N. J. Baxter, I. Whitehead, J. R. de Alaniz, and M. Z. Wilson
    Diels–Alder Photoclick Patterning of Extracellular Matrix for Spatially Controlled Cell Behaviors
    Advanced Materials
    35
    (2023)
    10.1002/adma.202303453
  • E. Q. Simmons, R. Sajjad, K. Keithley, H. Mas, J. L. Tanlimco, E. Nolasco-Martinez, Y. Bai, G. H. Fredrickson, and D. M. Weld
    Thermodynamic engine with a quantum degenerate working fluid
    Physical Review Research
    5
    (2023)
    10.1103/physrevresearch.5.l042009
  • K. R. Albanese, P. T. Morris, J. Read de Alaniz, C. M. Bates, and C. J. Hawker
    Controlled-Radical Polymerization of α-Lipoic Acid: A General Route to Degradable Vinyl Copolymers
    Journal of the American Chemical Society
    145
    22728-22734
    (2023)
    10.1021/jacs.3c08248
  • C. A. D'Ambra, M. Czuczola, P. T. Getty, E. A. Murphy, A. Abdilla, S. Biswas, J. M. Mecca, T. D. Bekemeier, S. Swier, C. J. Hawker, and C. M. Bates
    Versatile synthesis of siloxane‐based graft copolymers with tunable grafting density
    Journal of Polymer Science
    62
    92-101
    (2023)
    10.1002/pol.20230615
  • S. Ju, K. P. Kuzelka, R. Guo, B. Krohn-Hansen, J. Wu, S. K. Nair, and Y. Yang
    A biocatalytic platform for asymmetric alkylation of α-keto acids by mining and engineering of methyltransferases
    Nature Communications
    14
    (2023)
    10.1038/s41467-023-40980-w
  • A. L. Chau, C. D. Pugsley, M. E. Miyamoto, Y. Tang, C. D. Eisenbach, T. E. Mates, C. J. Hawker, M. T. Valentine, and A. A. Pitenis
    pH-Dependent Friction of Polyacrylamide Hydrogels
    Tribology Letters
    71
    (2023)
    10.1007/s11249-023-01779-4
  • M. Nguyen, K. Shen, N. Sherck, S. Köhler, R. Gupta, K. T. Delaney, M. S. Shell, and G. H. Fredrickson
    A molecularly informed field-theoretic study of the complexation of polycation PDADMA with mixed micelles of sodium dodecyl sulfate and ethoxylated surfactants
    The European Physical Journal E
    46
    (2023)
    10.1140/epje/s10189-023-00332-4
  • M. L. Le, I. Lapkriengkri, K. R. Albanese, P. H. Nguyen, C. Tran, J. R. Blankenship, R. A. Segalman, C. M. Bates, and M. L. Chabinyc
    Engineering Soft, Elastic, and Conductive Polymers for Stretchable Electronics Using Ionic Compatibilization
    Chemistry of Materials
    35
    7301-7310
    (2023)
    10.1021/acs.chemmater.3c01685
  • M. Gu, X. Fang, and Y. Luo
    Data-Driven Model Construction for Anisotropic Dynamics of Active Matter
    PRX Life
    1
    (2023)
    10.1103/prxlife.1.013009
  • R. C. Law, G. Nurwono, and J. O. Park
    A parallel glycolysis provides a selective advantage through rapid growth acceleration
    Nature Chemical Biology
    20
    314-322
    (2023)
    10.1038/s41589-023-01395-2
  • L. Cheng, D. Li, B. K. Mai, Z. Bo, L. Cheng, P. Liu, and Y. Yang
    Stereoselective amino acid synthesis by synergistic photoredox-pyridoxal radical biocatalysis
    Science
    381
    444-451
    (2023)
    10.1126/science.adg2420
  • N. J. Sinha, K. C. Cunha, R. Murphy, C. J. Hawker, J. Shea, and M. E. Helgeson
    Competition between β-Sheet and Coacervate Domains Yields Diverse Morphologies in Mixtures of Oppositely Charged Homochiral Polypeptides
    Biomacromolecules
    24
    3580-3588
    (2023)
    10.1021/acs.biomac.3c00361
  • W. Fu, N. M. Neris, Y. Fu, Y. Zhao, B. Krohn-Hansen, P. Liu, and Y. Yang
    Enzyme-controlled stereoselective radical cyclization to arenes enabled by metalloredox biocatalysis
    Nature Catalysis
    6
    628-636
    (2023)
    10.1038/s41929-023-00986-5
  • K. R. Albanese, J. R. Blankenship, T. Quah, A. Zhang, K. T. Delaney, G. H. Fredrickson, C. M. Bates, and C. J. Hawker
    Improved Elastic Recovery from ABC Triblock Terpolymers
    ACS Polymers Au
    3
    376-382
    (2023)
    10.1021/acspolymersau.3c00012
  • R. V. Garcia, E. A. Murphy, N. J. Sinha, Y. Okayama, J. M. Urueña, M. E. Helgeson, C. M. Bates, C. J. Hawker, R. D. Murphy, and J. Read de Alaniz
    Tailoring Writability and Performance of Star Block Copolypeptides Hydrogels through Side‐Chain Design
    Small
    19
    (2023)
    10.1002/smll.202302794
  • Y. Luo, M. Gu, M. Park, X. Fang, Y. Kwon, J. M. Urueña, J. Read de Alaniz, M. E. Helgeson, C. M. Marchetti, and M. T. Valentine
    Molecular-scale substrate anisotropy, crowding and division drive collective behaviours in cell monolayers
    Journal of The Royal Society Interface
    20
    (2023)
    10.1098/rsif.2023.0160
  • J. Gao, S. Liu, C. Zhou, D. Lara, Y. Zou, and Y. Hai
    A pyridoxal 5′-phosphate-dependent Mannich cyclase
    Nature Catalysis
    6
    476-486
    (2023)
    10.1038/s41929-023-00963-y
  • K. R. Albanese, Y. Okayama, P. T. Morris, M. Gerst, R. Gupta, J. C. Speros, C. J. Hawker, C. Choi, J. R. de Alaniz, and C. M. Bates
    Building Tunable Degradation into High-Performance Poly(acrylate) Pressure-Sensitive Adhesives
    ACS Macro Letters
    12
    787-793
    (2023)
    10.1021/acsmacrolett.3c00204
  • D. P. Shannon, J. D. Moon, C. W. Barney, N. J. Sinha, K. Yang, S. D. Jones, R. V. Garcia, M. E. Helgeson, R. A. Segalman, M. T. Valentine, and C. J. Hawker
    Modular Synthesis and Patterning of High-Stiffness Networks by Postpolymerization Functionalization with Iron–Catechol Complexes
    Macromolecules
    56
    2268-2276
    (2023)
    10.1021/acs.macromol.2c02561
  • Z. Yao, Y. Kuang, P. Kohl, Y. Li, and H. A. M. Ardoña
    Carbodiimide‐Fueled Assembly of π‐Conjugated Peptides Regulated by Electrostatic Interactions**
    ChemSystemsChem
    5
    (2023)
    10.1002/syst.202300003
  • S. J. Bailey, E. Hopkins, K. D. Rael, A. Hashmi, J. M. Urueña, M. Z. Wilson, and J. Read de Alaniz
    Design, Synthesis, and Application of a Water‐soluble Photocage for Aqueous Cyclopentadiene‐based Diels‐Alder Photoclick Chemistry in Hydrogels
    Angewandte Chemie International Edition
    62
    (2023)
    10.1002/anie.202301157
  • D. J. Atkins, A. L. Chau, J. M. Rosas, Y. Chen, S. T. Chan, J. Manuel Urueña, and A. A. Pitenis
    Silicone implant surface roughness, friction, and wear
    Surface Topography: Metrology and Properties
    11
    014010
    (2023)
    10.1088/2051-672x/ac9f5a
  • P. Salas-Ambrosio, S. Vexler, R. P S, I. A. Chen, and H. D. Maynard
    Caffeine and Cationic Copolymers with Antimicrobial Properties
    ACS Bio & Med Chem Au
    3
    189-200
    (2023)
    10.1021/acsbiomedchemau.2c00077
  • T. M. Tran, and J. R. de Alaniz
    Controlled Synthesis of a Homopolymer Network Using a Well-Defined Single-Component Diels–Alder Cyclopentadiene Monomer
    Journal of the American Chemical Society
    145
    3462-3469
    (2023)
    10.1021/jacs.2c11416
  • K. Bell, B. Hunter, M. Alvarez, S. D. K. Seera, Y. Guo, Y. Lin, S. H. Kim, and C. W. Pester
    Hydrolysis-resistant heterogeneous photocatalysts for PET-RAFT polymerization in aqueous environments
    Journal of Materials Chemistry A
    11
    16616-16625
    (2023)
    10.1039/d3ta02582a
  • R. D. Murphy, R. V. Garcia, S. J. Oh, T. J. Wood, K. D. Jo, J. Read de Alaniz, E. Perkins, and C. J. Hawker
    Tailored Polypeptide Star Copolymers for 3D Printing of Bacterial Composites Via Direct Ink Writing
    Advanced Materials
    35
    (2022)
    10.1002/adma.202207542
  • X. Fang, M. Gu, and J. Wu
    Reliable emulation of complex functionals by active learning with error control
    The Journal of Chemical Physics
    157
    (2022)
    10.1063/5.0121805
  • J. M. Rosas, D. J. Atkins, A. L. Chau, Y. Chen, R. Bae, M. K. Cavanaugh, R. I. Espinosa Lima, A. Bordeos, M. G. Bryant, and A. A. Pitenis
    In vitro models of soft tissue damage by implant-associated frictional shear stresses
    Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology
    237
    1264-1271
    (2022)
    10.1177/13506501221132897
  • N. L. Forsythe, M. F. Tan, D. Vinciguerra, J. Woodford, A. Z. Stieg, and H. D. Maynard
    Noncovalent Enzyme Nanogels via a Photocleavable Linkage
    Macromolecules
    55
    9925-9933
    (2022)
    10.1021/acs.macromol.2c01334
  • J. Jang, C. Choi, K. Kim, Y. Okayama, J. H. Lee, J. Read de Alaniz, C. M. Bates, and J. K. Kim
    Triboelectric Nanogenerators: Enhancing Performance by Increasing the Charge-Generating Layer Compressibility
    ACS Macro Letters
    11
    1291-1297
    (2022)
    10.1021/acsmacrolett.2c00535
  • J. Chen, A. Rizvi, J. P. Patterson, and C. J. Hawker
    Discrete Libraries of Amphiphilic Poly(ethylene glycol) Graft Copolymers: Synthesis, Assembly, and Bioactivity
    Journal of the American Chemical Society
    144
    19466-19474
    (2022)
    10.1021/jacs.2c07859
  • E. A. Murphy, Y. Chen, K. Albanese, J. R. Blankenship, A. Abdilla, M. W. Bates, C. Zhang, C. M. Bates, and C. J. Hawker
    Efficient Creation and Morphological Analysis of ABC Triblock Terpolymer Libraries
    Macromolecules
    55
    8875-8882
    (2022)
    10.1021/acs.macromol.2c01480
  • Y. Chen, H. L. Chan, B. C. Regan, and M. Mecklenburg
    In Situ Transmission Kikuchi Diffraction Observation of Thin-Film GST Crystal Phase and Grain Evolution
    Microscopy and Microanalysis
    28
    2314-2315
    (2022)
    10.1017/s1431927622008893
  • Y. Chen, J. J. Lodico, X. Y. Ling, B. C. Regan, and M. Mecklenburg
    Detecting Temperature-Induced Strain Changes using In Situ Transmission Kikuchi Diffraction
    Microscopy and Microanalysis
    28
    576-577
    (2022)
    10.1017/s1431927622002884
  • Y. Fu, H. Chen, W. Fu, M. Garcia-Borràs, Y. Yang, and P. Liu
    Engineered P450 Atom-Transfer Radical Cyclases are Bifunctional Biocatalysts: Reaction Mechanism and Origin of Enantioselectivity
    Journal of the American Chemical Society
    144
    13344-13355
    (2022)
    10.1021/jacs.2c04937
  • L. K. Månsson, A. A. Pitenis, and M. Z. Wilson
    Extracellular Optogenetics at the Interface of Synthetic Biology and Materials Science
    Frontiers in Bioengineering and Biotechnology
    10
    (2022)
    10.3389/fbioe.2022.903982
  • B. K. Mai, N. M. Neris, Y. Yang, and P. Liu
    C–N Bond Forming Radical Rebound Is the Enantioselectivity-Determining Step in P411-Catalyzed Enantioselective C(sp3)–H Amination: A Combined Computational and Experimental Investigation
    Journal of the American Chemical Society
    144
    11215-11225
    (2022)
    10.1021/jacs.2c02283
  • J. Misa, J. M. Billingsley, K. Niwa, R. K. Yu, and Y. Tang
    Engineered Production of Strictosidine and Analogues in Yeast
    ACS Synthetic Biology
    11
    1639-1649
    (2022)
    10.1021/acssynbio.2c00037
  • C. Choi, Y. Okayama, P. T. Morris, L. L. Robinson, M. Gerst, J. C. Speros, C. J. Hawker, J. Read de Alaniz, and C. M. Bates
    Digital Light Processing of Dynamic Bottlebrush Materials
    Advanced Functional Materials
    32
    (2022)
    10.1002/adfm.202200883
  • C. W. Barney, M. T. Valentine, and M. E. Helgeson
    Strength of fluid-filled soft composites across the elastofracture length
    Soft Matter
    18
    4897-4904
    (2022)
    10.1039/d2sm00177b
  • S. J. Bailey, C. W. Barney, N. J. Sinha, S. V. Pangali, C. J. Hawker, M. E. Helgeson, M. T. Valentine, and J. Read de Alaniz
    Rational mechanochemical design of Diels–Alder crosslinked biocompatible hydrogels with enhanced properties
    Materials Horizons
    9
    1947-1953
    (2022)
    10.1039/d2mh00338d
  • Y. Luo, M. Gu, C. E. R. Edwards, M. T. Valentine, and M. E. Helgeson
    High-throughput microscopy to determine morphology, microrheology, and phase boundaries applied to phase separating coacervates
    Soft Matter
    18
    3063-3075
    (2022)
    10.1039/d1sm01763b
  • Q. Zhou, M. Chin, Y. Fu, P. Liu, and Y. Yang
    Stereodivergent atom-transfer radical cyclization by engineered cytochromes P450
    Science
    374
    1612-1616
    (2021)
    10.1126/science.abk1603
  • M. Gu, Y. Luo, Y. He, M. E. Helgeson, and M. T. Valentine
    Uncertainty quantification and estimation in differential dynamic microscopy
    Physical Review E
    104
    (2021)
    10.1103/physreve.104.034610
  • I. C. Okorafor, M. Chen, and Y. Tang
    High-Titer Production of Olivetolic Acid and Analogs in Engineered Fungal Host Using a Nonplant Biosynthetic Pathway
    ACS Synthetic Biology
    10
    2159-2166
    (2021)
    10.1021/acssynbio.1c00309
  • S. J. Bailey, F. Stricker, E. Hopkins, M. Z. Wilson, and J. Read de Alaniz
    Shining Light on Cyclopentadienone–Norbornadiene Diels–Alder Adducts to Enable Photoinduced Click Chemistry with Cyclopentadiene
    ACS Applied Materials & Interfaces
    13
    35422-35430
    (2021)
    10.1021/acsami.1c08670
  • L. L. Robinson, J. L. Self, A. D. Fusi, M. W. Bates, J. Read de Alaniz, C. J. Hawker, C. M. Bates, and C. S. Sample
    Chemical and Mechanical Tunability of 3D-Printed Dynamic Covalent Networks Based on Boronate Esters
    ACS Macro Letters
    10
    857-863
    (2021)
    10.1021/acsmacrolett.1c00257
  • R. Cerbino, F. Giavazzi, and M. E. Helgeson
    Differential dynamic microscopy for the characterization of polymer systems
    Journal of Polymer Science
    60
    1079-1089
    (2021)
    10.1002/pol.20210217
View All Publications
People
  • Javier Read de Alaniz
    Director, NSF BioPACIFIC MIP Professor
  • Heather Maynard
    Co-Director, NSF BioPACIFIC MIP Professor
    Chemistry, Biochemistry, and Bioengineering
  • Adam Stieg
    Executive Director
    NSF BioPACIFIC MIP
  • Tal Margalith
    Executive Director
    NSF BioPACIFIC MIP
  • Craig Hawker
    Co-PI, NSF BioPACIFIC MIP Professor
    Materials, Chemistry, and Biochemistry
  • Yi Tang
    Co-PI, NSF BioPACIFIC MIP Professor
    Chemical and Biomolecular Engineering, Chemistry and Biochemistry
View All People
Universities