BioPolymers, Automated Cellular Infrastructure, Flow, and Integrated Chemistry Materials Innovation Platform (BioPACIFIC MIP)
The NSF BioPACIFIC MIP (DMR-1933487) merges advances in synthetic biology and synthetic chemistry by providing access to scientific expertise, multiscale computation and simulation for materials design, and advanced instrumentation capabilities to enable data-driven discovery and scalable production of bio-derived building blocks and polymers from yeast, fungi and bacteria, and the conversion of these blocks into next-generation polymers with properties and performance far exceeding those currently available in materials produced through traditional petrochemical-based methods.
BioPACIFIC MIP operates a one of a kind user facility dedicated to creating a nexus for synthetic biology and materials. Users are uniquely able to elucidate biomaterial structure and function to achieve materials-by-design, construct new bio-derived functional monomers from living organisms, access novel sequence-specific materials (e.g. peptoids), synthesize stimuli-responsive “smart” biomaterials, scale-up biomaterial production, and incorporate state-of-the-art field-theoretic simulation and machine learning algorithms.
In all cases, this platform is made possible by the unique and collective expertise of the BioPACIFIC MIP faculty and staff. BioPACIFIC MIP facilities are open to all US scientists via a peer-reviewed User Proposal process.
Publications
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Topochemical Synthesis, micro-Electron Diffraction (3D ED), and Electron Beam-Initiated Topotactic Dimer Splitting of cis,syn-Thymine Dimer CrystalsJournal of the American Chemical Society(2025)
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Combating Reactive Oxygen Species (ROS) with Antioxidant Supramolecular PolymersACS Applied Materials & Interfaces(2025)
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Biosourced Functional Hydroxybenzoate-co-Lactide Polymers with Antimicrobial ActivityJournal of the American Chemical Society14719230-19238(2025)
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Versatile Liquid Crystal Elastomer Formulations Using Amine-Acrylate Chemistry and Processing for Advanced ManufacturingACS Applied Engineering Materials31389-1398(2025)
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Imaging-guided deep tissue in vivo sound printingScience388616-623(2025)
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Designing Highly Conductive Anion Exchange Membranes: Tuning Domain Continuity with ABC Block Copolymer Self-AssemblyJournal of the American Chemical Society14716471-16480(2025)
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Microstructural Rearrangements in Triblock Polyelectrolyte Complex HydrogelsACS Macro Letters14544-550(2025)
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Imaging the Progression of Radiolytic Damage in Molecular Crystals with Scanning Nanobeam Electron DiffractionPhysical Review Letters134(2025)
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Cell‐Sheet Shape Transformation by Internally‐Driven, Oriented ForcesAdvanced Materials37(2025)
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Catalytic Enantioselective Smiles Rearrangement Enabled by the Directed Evolution of P450 Radical Aryl MigratasesJournal of the American Chemical Society14712197-12205(2025)
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Latent Thermal Transformation of 3D-Printed Polymer Composite Foams Provides Tailored Mechanical PropertiesACS Applied Polymer Materials74142-4152(2025)
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Improvement of Carbon Black Dispersion in Mussel-Inspired Composites from Epoxidized Natural Rubber Using Aromatic InteractionsACS Applied Polymer Materials73576-3587(2025)
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Accounting for electron-beam-induced warping of molecular nanocrystals in MicroED structure determinationIUCrJ12223-238(2025)
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Universal Phase Identification of Block Copolymers From Physics‐Informed Machine LearningJournal of Polymer Science631433-1440(2025)
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Injectable Fluorescent Bottlebrush Polymers for Interventional Procedures and Biomedical ImagingBiomacromolecules261234-1250(2025)
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Enhanced Degradation of Vinyl Copolymers Based on Lipoic AcidJournal of Polymer Science631345-1351(2025)
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Mesoscopic Morphologies in Frustrated ABC Bottlebrush Block TerpolymersACS Nano191211-1221(2025)
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Projected complex Langevin sampling method for bosons in the canonical and microcanonical ensemblesPhysical Review E110(2024)
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The Precise Synthesis of Ultradense Bottlebrush Polymers Unearths Unique Trends in Lyotropic OrderingJournal of the American Chemical Society147889-897(2024)
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Data-Driven Framework for the Prediction of PEGDA Hydrogel MechanicsACS Biomaterials Science & Engineering11259-267(2024)
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Telechelic Dithiol Copolymers as Tunable Building Blocks for Synthesizing Multiblock MaterialsJournal of Polymer Science63759-765(2024)
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Bioinspired Metal–Ligand Networks with Enhanced Stability and Performance: Facile Preparation of Hydroxypyridinone (HOPO)-Functionalized MaterialsMacromolecules5711339-11349(2024)
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From Beam Damage to Massive Reaction Amplification under the Electron Microscope: An Ionization-Induced Chain Reaction in Crystals of a Dewar BenzeneACS Central Science102346-2352(2024)
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Resonant Soft X-ray Scattering Reveals the Distribution of Dopants in Semicrystalline Conjugated PolymersThe Journal of Physical Chemistry B12812597-12611(2024)
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3D Printing of Functional Hydrogel Devices for Screenings of Membrane Permeability and SelectivityACS Applied Polymer Materials614629-14637(2024)
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Discrete Side Chains for Direct Tuning Properties of Grafted PolymersMacromolecules5711753-11762(2024)
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Stability of Frank–Kasper Phases in ABn Miktoarm Star Polymers with Dispersity in n: Simulations and ExperimentsMacromolecules5711289-11295(2024)
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Efficient Cross-Linking through C–H Bond Insertion of Unfunctionalized Commodity Materials Using Diazirine-Containing PolymersACS Macro Letters131598-1604(2024)
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Cyclic stretch regulates epithelial cell migration in a frequency dependent manner via intercellular vinculin recruitmentnpj Biological Physics and Mechanics1(2024)
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Engineering battery corrosion films by tuning electrical double layer compositionJoule83038-3053(2024)
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Scalable Synthesis of Degradable Copolymers Containing α-Lipoic Acid via Miniemulsion PolymerizationJournal of the American Chemical Society14630662-30667(2024)
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Sustainable and Recyclable Acrylate Resins for Liquid-Crystal Display 3D Printing Based on Lipoic AcidACS Macro Letters131495-1502(2024)
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Thermodynamic stability of a spin microemulsion in Rashba spin-orbit-coupled bosonsPhysical Review A110(2024)
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Accelerated Prediction of Phase Behavior for Block Copolymer Libraries Using a Molecularly Informed Field TheoryJournal of the American Chemical Society14629751-29758(2024)
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A Gram–Charlier Analysis of Scattering to Describe Nonideal Polymer ConformationsMacromolecules579518-9535(2024)
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Emergence of Disordered Hyperuniformity in Melts of Linear Diblock CopolymersMacromolecules579911-9919(2024)
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A Glucose-Responsive Glucagon-Micelle for the Prevention of HypoglycemiaACS Central Science102036-2047(2024)
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Crosslinked Natural Rubber and Styrene Butadiene Rubber Blends/Carbon Black Composites for Self-healable and Energy-saved ApplicationsChinese Journal of Polymer Science421835-1844(2024)
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Ab initio uncertainty quantification in scattering analysis of microscopyPhysical Review E110(2024)
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A colloidal model for the equilibrium assembly and liquid-liquid phase separation of the reflectin A1 proteinBiophysical Journal1233065-3079(2024)
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A metalloenzyme platform for catalytic asymmetric radical dearomatizationNature Chemistry161999-2008(2024)
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Multiscale Computational Study of Cellulose Acetate–Water Miscibility: Insights from Molecularly Informed Field-Theoretic ModelingBiomacromolecules255809-5818(2024)
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Sequence and gelation in supramolecular polymersThe Journal of Chemical Physics161(2024)
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Machine learning-guided co-optimization of fitness and diversity facilitates combinatorial library design in enzyme engineeringNature Communications15(2024)
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Synthesis and Thermo-Selective Recycling of Diels–Alder Cyclopentadiene ThermoplasticsJournal of the American Chemical Society14620972-20981(2024)
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Synthesis, molecular and crystal structures of 4-amino-3,5-difluorobenzonitrile, ethyl 4-amino-3,5-difluorobenzoate, and diethyl 4,4′-(diazene-1,2-diyl)bis(3,5-difluorobenzoate)Acta Crystallographica Section E Crystallographic Communications80867-872(2024)
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Understanding the Response of Poly(ethylene glycol) diacrylate (PEGDA) Hydrogel Networks: A Statistical Mechanics-Based FrameworkMacromolecules577074-7086(2024)
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Polypeptoid Monomer Sequence and Chemical Composition as Independent Controls of Interfacial Tension and Elasticity at Air/Fluid InterfacesLangmuir4015353-15362(2024)
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Salt-Screened Transition toward Bulk-Like Water Dynamics near Polymeric ZwitterionsACS Macro Letters13928-934(2024)
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Imaging by Diffraction in Transmission Electron MicroscopyMicroscopy and Microanalysis30(2024)
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Spatially Resolved Components in Battery Corrosion Films by 4D STEMMicroscopy and Microanalysis30(2024)
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Selective electrochemical degradation of bottlebrush elastomersJournal of Polymer Science624326-4331(2024)
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Paths to Attenuate Radiolysis-Induced Secondary Damage in Biological CryoEMMicroscopy and Microanalysis30(2024)
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Comparing Multifunctional Viral and Eukaryotic Proteins for Generating Scission Necks in MembranesACS Nano1815545-15556(2024)
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Facile Preparation of Tunable Polyborosiloxane Networks via HydrosilylationChemistry of Materials365935-5942(2024)
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From health supplement to versatile monomer: Radical ring-opening polymerization and depolymerization of α-lipoic acidPolymer304127167(2024)
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Application of Transformers in CheminformaticsJournal of Chemical Information and Modeling644392-4409(2024)
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Comparison of Cyclic and Linear PEG ConjugatesBioconjugate Chemistry35744-749(2024)
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Stereoselective amino acid synthesis by photobiocatalytic oxidative couplingNature62998-104(2024)
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Bioinspired Lubricity from Surface Gel LayersLangmuir409926-9933(2024)
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Biocatalytic enantioselective C(sp3)–H fluorination enabled by directed evolution of non-haem iron enzymesNature Synthesis3967-975(2024)
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Understanding the Nucleation and Growth of ZIF-8 PolymorphsCrystal Growth & Design244136-4142(2024)
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Stereodivergent photobiocatalytic radical cyclization through the repurposing and directed evolution of fatty acid photodecarboxylasesNature Chemistry161339-1347(2024)
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How Fungi Biosynthesize 3-Nitropropanoic Acid: The Simplest yet Lethal MycotoxinOrganic Letters263158-3163(2024)
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Crystallization-Induced Flower-like Superstructures via Peptoid Helix AssemblyACS Macro Letters13423-428(2024)
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Chromatographic Separation: A Versatile Strategy to Prepare Discrete and Well-Defined Polymer LibrariesAccounts of Chemical Research571202-1213(2024)
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High-Throughput Synthesis, Purification, and Application of Alkyne-Functionalized Discrete OligomersJournal of the American Chemical Society1468650-8658(2024)
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Survival-Associated Cellular Response Maintained in Pancreatic Ductal Adenocarcinoma (PDAC) Switched Between Soft and Stiff 3D Microgel CultureACS Biomaterials Science & Engineering102177-2187(2024)
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Cylinders-in-Undulating-Lamellae Morphology from ABC Bottlebrush Block TerpolymersJournal of the American Chemical Society1466796-6805(2024)
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Block Polyelectrolyte Additives That Modulate the Viscoelasticity and Enhance the Printability of Gelatin Inks at Physiological TemperaturesACS Applied Polymer Materials62427-2441(2024)
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Control over Conformational Landscapes of Polypeptoids by Monomer Sequence PatterningMacromolecules571469-1477(2024)
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Accelerated discovery and mapping of block copolymer phase diagramsPhysical Review Materials8(2024)
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Experimental observation of near-wall effects during the puncture of soft solidsSoft Matter203806-3813(2024)
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Quantitative turbidimetric characterization of stabilized complex coacervate dispersionsSoft Matter205060-5070(2024)
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Evaluating polymerization kinetics using microrheologyPolymer Chemistry151758-1766(2024)
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Molecularly informed field theory for estimating critical micelle concentrations of intrinsically disordered protein surfactantsThe Journal of Chemical Physics159(2023)
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Engineered biosynthesis of plant heteroyohimbine and corynantheine alkaloids in Saccharomyces cerevisiaeJournal of Industrial Microbiology and Biotechnology51(2023)
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Heterotelechelic Silicones: Facile Synthesis and Functionalization Using Silane-Based InitiatorsMacromolecules568806-8812(2023)
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Single-Molecule Polypeptoid Stretching Reveals the Effects of Charge Sequence on Chain ConformationMacromolecules568558-8564(2023)
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Emergence of a Spin Microemulsion in Spin-Orbit Coupled Bose-Einstein CondensatesPhysical Review Letters131(2023)
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Diels–Alder Photoclick Patterning of Extracellular Matrix for Spatially Controlled Cell BehaviorsAdvanced Materials35(2023)
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Thermodynamic engine with a quantum degenerate working fluidPhysical Review Research5(2023)
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Controlled-Radical Polymerization of α-Lipoic Acid: A General Route to Degradable Vinyl CopolymersJournal of the American Chemical Society14522728-22734(2023)
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Versatile synthesis of siloxane‐based graft copolymers with tunable grafting densityJournal of Polymer Science6292-101(2023)
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A biocatalytic platform for asymmetric alkylation of α-keto acids by mining and engineering of methyltransferasesNature Communications14(2023)
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pH-Dependent Friction of Polyacrylamide HydrogelsTribology Letters71(2023)
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A molecularly informed field-theoretic study of the complexation of polycation PDADMA with mixed micelles of sodium dodecyl sulfate and ethoxylated surfactantsThe European Physical Journal E46(2023)
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Engineering Soft, Elastic, and Conductive Polymers for Stretchable Electronics Using Ionic CompatibilizationChemistry of Materials357301-7310(2023)
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Data-Driven Model Construction for Anisotropic Dynamics of Active MatterPRX Life1(2023)
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A parallel glycolysis provides a selective advantage through rapid growth accelerationNature Chemical Biology20314-322(2023)
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Stereoselective amino acid synthesis by synergistic photoredox-pyridoxal radical biocatalysisScience381444-451(2023)
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Competition between β-Sheet and Coacervate Domains Yields Diverse Morphologies in Mixtures of Oppositely Charged Homochiral PolypeptidesBiomacromolecules243580-3588(2023)
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Enzyme-controlled stereoselective radical cyclization to arenes enabled by metalloredox biocatalysisNature Catalysis6628-636(2023)
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Improved Elastic Recovery from ABC Triblock TerpolymersACS Polymers Au3376-382(2023)
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Tailoring Writability and Performance of Star Block Copolypeptides Hydrogels through Side‐Chain DesignSmall19(2023)
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Molecular-scale substrate anisotropy, crowding and division drive collective behaviours in cell monolayersJournal of The Royal Society Interface20(2023)
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A pyridoxal 5′-phosphate-dependent Mannich cyclaseNature Catalysis6476-486(2023)
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Building Tunable Degradation into High-Performance Poly(acrylate) Pressure-Sensitive AdhesivesACS Macro Letters12787-793(2023)
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Modular Synthesis and Patterning of High-Stiffness Networks by Postpolymerization Functionalization with Iron–Catechol ComplexesMacromolecules562268-2276(2023)
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Carbodiimide‐Fueled Assembly of π‐Conjugated Peptides Regulated by Electrostatic Interactions**ChemSystemsChem5(2023)
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Design, Synthesis, and Application of a Water‐soluble Photocage for Aqueous Cyclopentadiene‐based Diels‐Alder Photoclick Chemistry in HydrogelsAngewandte Chemie International Edition62(2023)
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Silicone implant surface roughness, friction, and wearSurface Topography: Metrology and Properties11014010(2023)
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Caffeine and Cationic Copolymers with Antimicrobial PropertiesACS Bio & Med Chem Au3189-200(2023)
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Controlled Synthesis of a Homopolymer Network Using a Well-Defined Single-Component Diels–Alder Cyclopentadiene MonomerJournal of the American Chemical Society1453462-3469(2023)
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Hydrolysis-resistant heterogeneous photocatalysts for PET-RAFT polymerization in aqueous environmentsJournal of Materials Chemistry A1116616-16625(2023)
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Tailored Polypeptide Star Copolymers for 3D Printing of Bacterial Composites Via Direct Ink WritingAdvanced Materials35(2022)
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Reliable emulation of complex functionals by active learning with error controlThe Journal of Chemical Physics157(2022)
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In vitro models of soft tissue damage by implant-associated frictional shear stressesProceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology2371264-1271(2022)
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Noncovalent Enzyme Nanogels via a Photocleavable LinkageMacromolecules559925-9933(2022)
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Triboelectric Nanogenerators: Enhancing Performance by Increasing the Charge-Generating Layer CompressibilityACS Macro Letters111291-1297(2022)
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Discrete Libraries of Amphiphilic Poly(ethylene glycol) Graft Copolymers: Synthesis, Assembly, and BioactivityJournal of the American Chemical Society14419466-19474(2022)
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Efficient Creation and Morphological Analysis of ABC Triblock Terpolymer LibrariesMacromolecules558875-8882(2022)
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In Situ Transmission Kikuchi Diffraction Observation of Thin-Film GST Crystal Phase and Grain EvolutionMicroscopy and Microanalysis282314-2315(2022)
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Detecting Temperature-Induced Strain Changes using In Situ Transmission Kikuchi DiffractionMicroscopy and Microanalysis28576-577(2022)
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Engineered P450 Atom-Transfer Radical Cyclases are Bifunctional Biocatalysts: Reaction Mechanism and Origin of EnantioselectivityJournal of the American Chemical Society14413344-13355(2022)
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Extracellular Optogenetics at the Interface of Synthetic Biology and Materials ScienceFrontiers in Bioengineering and Biotechnology10(2022)
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C–N Bond Forming Radical Rebound Is the Enantioselectivity-Determining Step in P411-Catalyzed Enantioselective C(sp3)–H Amination: A Combined Computational and Experimental InvestigationJournal of the American Chemical Society14411215-11225(2022)
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Engineered Production of Strictosidine and Analogues in YeastACS Synthetic Biology111639-1649(2022)
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Digital Light Processing of Dynamic Bottlebrush MaterialsAdvanced Functional Materials32(2022)
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Strength of fluid-filled soft composites across the elastofracture lengthSoft Matter184897-4904(2022)
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Rational mechanochemical design of Diels–Alder crosslinked biocompatible hydrogels with enhanced propertiesMaterials Horizons91947-1953(2022)
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High-throughput microscopy to determine morphology, microrheology, and phase boundaries applied to phase separating coacervatesSoft Matter183063-3075(2022)
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Stereodivergent atom-transfer radical cyclization by engineered cytochromes P450Science3741612-1616(2021)
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Uncertainty quantification and estimation in differential dynamic microscopyPhysical Review E104(2021)
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High-Titer Production of Olivetolic Acid and Analogs in Engineered Fungal Host Using a Nonplant Biosynthetic PathwayACS Synthetic Biology102159-2166(2021)
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Shining Light on Cyclopentadienone–Norbornadiene Diels–Alder Adducts to Enable Photoinduced Click Chemistry with CyclopentadieneACS Applied Materials & Interfaces1335422-35430(2021)
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Chemical and Mechanical Tunability of 3D-Printed Dynamic Covalent Networks Based on Boronate EstersACS Macro Letters10857-863(2021)
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Differential dynamic microscopy for the characterization of polymer systemsJournal of Polymer Science601079-1089(2021)

People
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Javier Read de AlanizDirector, NSF BioPACIFIC MIP Professor
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Heather MaynardCo-Director, NSF BioPACIFIC MIP ProfessorChemistry, Biochemistry, and Bioengineering
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Adam StiegExecutive DirectorNSF BioPACIFIC MIP
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Tal MargalithExecutive DirectorNSF BioPACIFIC MIP
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Craig HawkerCo-PI, NSF BioPACIFIC MIP ProfessorMaterials, Chemistry, and Biochemistry
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Yi TangCo-PI, NSF BioPACIFIC MIP ProfessorChemical and Biomolecular Engineering, Chemistry and Biochemistry
Universities

