GlycoMIP

GlycoMIP is an NSF-funded national user facility and multidisciplinary research program that addresses scientific and technological bottlenecks in glycomaterials research. A partnership between Virginia Tech, the University of Georgia, Brandeis University, and Rensselaer Polytechnic Institute, GlycoMIP accelerates glycomaterials discovery and development through leading-edge research and a state-of-the-art user facility.

Publications

  • B. M. Shumberger, K. C. Pearce, and T. D. Crawford
    Analytic Computation of Vibrational Circular Dichroism Spectra Using Second-Order Møller–Plesset Perturbation Theory
    Journal of Chemical Theory and Computation
    21
    3504-3512
    (2025)
    10.1021/acs.jctc.5c00047
  • Y. Li, H. Xu, A. Kumar, D. Wang, C. Heiss, P. Azadi, and P. Hong
    TransPeakNet for solvent-aware 2D NMR prediction via multi-task pre-training and unsupervised learning
    Communications Chemistry
    8
    (2025)
    10.1038/s42004-025-01455-9
  • E. R. Duque, and E. E. Hood
    Increasing Glucose Yield from Cellulose in Ground Corn Using Plant-Made Recombinant Cellulases
    Industrial Biotechnology
    21
    47-54
    (2025)
    10.1089/ind.2024.0038
  • S. M. Felton, N. Akula, G. L. Kolling, P. Azadi, I. Black, A. Kumar, C. Heiss, J. Capobianco, J. Uknalis, J. A. Papin, and B. W. Berger
    Applying a polysaccharide lyase from Stenotrophomonas maltophilia to disrupt alginate exopolysaccharide produced by Pseudomonas aeruginosa clinical isolates
    Applied and Environmental Microbiology
    91
    (2025)
    10.1128/aem.01853-24
  • D. Ahiadorme, and D. Crich
    Entropy-enthalpy compensation in the methyl 5-thio-α-d-galactopyranoside–Jacalin interaction
    Carbohydrate Research
    547
    109305
    (2025)
    10.1016/j.carres.2024.109305
  • Y. Liu, X. Yue, J. Zhang, Z. Zhai, A. Moammeri, K. J. Edgar, A. S. Berahas, R. Al Kontar, and B. N. Johnson
    Scalable Accelerated Materials Discovery of Sustainable Polysaccharide-Based Hydrogels by Autonomous Experimentation and Collaborative Learning
    ACS Applied Materials & Interfaces
    16
    70310-70321
    (2024)
    10.1021/acsami.4c16614
  • J. Yang, P. Datta, K. Xia, V. H. Pomin, C. Wang, M. Qiao, R. J. Linhardt, J. S. Dordick, and F. Zhang
    Inhibition of sulfated glycans on the binding of dengue virus envelope protein to heparin
    Glycoconjugate Journal
    41
    371-380
    (2024)
    10.1007/s10719-024-10172-9
  • M. A. Rothermund, S. J. Koehler, and V. Vaissier Welborn
    Electric Fields in Polymeric Systems
    Chemical Reviews
    124
    13331-13369
    (2024)
    10.1021/acs.chemrev.4c00490
  • C. A. Williams, D. J. Stone, S. Y. Joshi, G. Yilmaz, P. Farzeen, S. Jeon, Z. Harris-Ryden, C. R. Becer, S. A. Deshmukh, and C. E. Callmann
    Systematic Evaluation of Macromolecular Carbohydrate-Lectin Recognition Using Precision Glycopolymers
    Biomacromolecules
    25
    7985-7994
    (2024)
    10.1021/acs.biomac.4c01245
  • L. E. Pepi, A. Shajahan, A. S. Gleinich, C. Heiss, and P. Azadi
    Overview of Glycosylation Studies of SARS-CoV-2
    Glycoprotein Analysis
    1-28
    (2024)
    10.1039/9781839166433-00001
  • C. A. McCutchin, K. J. Edgar, C. Chen, and P. M. Dove
    Silica–Biomacromolecule Interactions: Toward a Mechanistic Understanding of Silicification
    Biomacromolecules
    26
    43-84
    (2024)
    10.1021/acs.biomac.4c00674
  • M. Qiao, Z. Wang, J. Zhang, Y. Li, L. Chen, F. Zhang, J. S. Dordick, R. J. Linhardt, C. Cai, H. Huang, and X. Zhang
    Nanopore-regulated in situ polymerization for synthesis of homogeneous heparan sulfate with low dispersity
    Carbohydrate Polymers
    341
    122297
    (2024)
    10.1016/j.carbpol.2024.122297
  • R. A. Bataglioli, H. Kaur, J. Muller, E. Geddes, C. Champine, and B. B. Hsu
    A naturally derived biomaterial formulation for improved menstrual care
    Matter
    7
    2941-2958
    (2024)
    10.1016/j.matt.2024.06.028
  • S. Skeeters, K. Bagale, G. Stepanyuk, D. Thieker, A. Aguhob, K. K. Chan, B. Dutzar, S. Shalygin, A. Shajahan, X. Yang, P. A. DaRosa, E. Frazier, M. M. Sauer, L. Bogatzki, K. A. Byrnes-Blake, Y. Song, P. Azadi, E. Tarcha, L. Zhang, and E. Procko
    Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation
    Molecular Therapy - Methods & Clinical Development
    32
    101301
    (2024)
    10.1016/j.omtm.2024.101301
  • Y. Yu, Y. Song, Y. Zhao, N. Wang, B. Wei, R. J. Linhardt, J. S. Dordick, F. Zhang, and H. Wang
    Quality control, safety assessment and preparation approaches of low molecular weight heparin
    Carbohydrate Polymers
    339
    122216
    (2024)
    10.1016/j.carbpol.2024.122216
  • I. O. McMillan, L. Liang, G. Su, X. Song, K. Drago, H. Yang, C. Alvarez, A. Sood, J. Gibson, R. J. Woods, C. Wang, J. Liu, F. Zhang, T. J. Brett, and L. Wang
    TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acid
    Journal of Biological Chemistry
    300
    107691
    (2024)
    10.1016/j.jbc.2024.107691
  • N. R. B. Boase, E. R. Gillies, R. Goh, R. E. Kieltyka, J. B. Matson, F. Meng, A. Sanyal, and O. Sedláček
    Stimuli-Responsive Polymers at the Interface with Biology
    Biomacromolecules
    25
    5417-5436
    (2024)
    10.1021/acs.biomac.4c00690
  • K. W. Bollinger, U. Müh, K. L. Ocius, A. J. Apostolos, M. M. Pires, R. F. Helm, D. L. Popham, D. S. Weiss, and C. D. Ellermeier
    Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability
    Proceedings of the National Academy of Sciences
    121
    (2024)
    10.1073/pnas.2408540121
  • Z. Zhai, Y. Zhou, I. Sarkar, Y. Liu, Y. Yao, J. Zhang, M. J. Bortner, J. B. Matson, B. N. Johnson, and K. J. Edgar
    Synthesis and real-time characterization of self-healing, injectable, fast-gelling hydrogels based on alginate multi-reducing end polysaccharides (MREPs)
    Carbohydrate Polymers
    338
    122172
    (2024)
    10.1016/j.carbpol.2024.122172
  • Y. Song, A. Singh, M. M. Feroz, S. Xu, F. Zhang, W. Jin, A. Kumar, P. Azadi, D. W. Metzger, R. J. Linhardt, and J. S. Dordick
    Seaweed-derived fucoidans and rhamnan sulfates serve as potent anti-SARS-CoV-2 agents with potential for prophylaxis
    Carbohydrate Polymers
    337
    122156
    (2024)
    10.1016/j.carbpol.2024.122156
  • B. M. Knight, R. Mondal, N. Han, N. F. Pietra, B. A. Hall, K. J. Edgar, V. Vaissier Welborn, L. A. Madsen, J. J. De Yoreo, and P. M. Dove
    Kinetics of Calcite Nucleation onto Sulfated Chitosan Derivatives and Implications for Water–Polysaccharide Interactions during Crystallization of Sparingly Soluble Salts
    Crystal Growth & Design
    24
    6338-6353
    (2024)
    10.1021/acs.cgd.4c00602
  • Y. Song, D. Mena-Aguilar, C. L. Brown, W. J. Rhoads, R. F. Helm, A. Pruden, and M. A. Edwards
    Effects of Copper on Legionella pneumophila Revealed via Viability Assays and Proteomics
    Pathogens
    13
    563
    (2024)
    10.3390/pathogens13070563
  • R. F. N. Quadrado, Z. Zhai, M. Zavadinack, G. Klassen, M. Iacomini, K. J. Edgar, and A. R. Fajardo
    All-polysaccharide, self-healing, pH-sensitive, in situ-forming hydrogel of carboxymethyl chitosan and aldehyde-functionalized hydroxyethyl cellulose
    Carbohydrate Polymers
    336
    122105
    (2024)
    10.1016/j.carbpol.2024.122105
  • E. Kucukdeger, Y. Zhang, J. Zhang, Y. Liu, X. Jia, and B. N. Johnson
    Automated Characterization of Macroscale Tissue 3D Spatial Material Properties via Robotically-Directed Impedimetric Sensing
    IEEE Transactions on Automation Science and Engineering
    21
    3408-3420
    (2024)
    10.1109/tase.2023.3279338
  • H. Yue, P. Hong, and H. Liu
    Graph–Graph Similarity Network
    IEEE Transactions on Neural Networks and Learning Systems
    35
    9136-9146
    (2024)
    10.1109/tnnls.2022.3218936
  • A. T. Sose, T. Gustke, F. Wang, G. Anand, S. Pasupuleti, A. Savara, and S. A. Deshmukh
    Evaluation of Sampling Algorithms Used for Bayesian Uncertainty Quantification of Molecular Dynamics Force Fields
    Journal of Chemical Theory and Computation
    20
    5732-5742
    (2024)
    10.1021/acs.jctc.4c00130
  • A. F. Chinn, N. R. Williams, K. M. Miller, and J. B. Matson
    Polysaccharide‐based H2S donors: Thiol‐ene functionalization of amylopectin with H2S‐releasing N‐thiocarboxyanhydrides
    Journal of Polymer Science
    62
    4155-4164
    (2024)
    10.1002/pol.20240262
  • J. Chung, J. Zhang, A. I. Saimon, Y. Liu, B. N. Johnson, and Z. Kong
    Imbalanced spectral data analysis using data augmentation based on the generative adversarial network
    Scientific Reports
    14
    (2024)
    10.1038/s41598-024-63285-4
  • J. O. Cisar, X. Wang, R. J. Woods, K. D. Cain, and G. D. Wiens
    Structural and genetic basis for the binding of a mouse monoclonal antibody to Flavobacterium psychrophilum lipopolysaccharide
    Journal of Fish Diseases
    (2024)
    10.1111/jfd.13958
  • J. Chung, J. Li, A. I. Saimon, P. Hong, and Z. Kong
    Predicting the stereoselectivity of chemical reactions by composite machine learning method
    Scientific Reports
    14
    (2024)
    10.1038/s41598-024-62158-0
  • M. G. Lei, M. A. Jorgenson, E. J. Robbs, I. M. Black, S. Archer-Hartmann, S. Shalygin, P. Azadi, and C. Y. Lee
    Characterization of Ssc, an N -acetylgalactosamine-containing Staphylococcus aureus surface polysaccharide
    Journal of Bacteriology
    206
    (2024)
    10.1128/jb.00048-24
  • J. Yang, Y. Song, K. Xia, V. H. Pomin, C. Wang, M. Qiao, R. J. Linhardt, J. S. Dordick, and F. Zhang
    Marine-Derived Sulfated Glycans Inhibit the Interaction of Heparin with Adhesion Proteins of Mycoplasma pneumoniae
    Marine Drugs
    22
    232
    (2024)
    10.3390/md22050232
  • J. E. Thompson, and K. J. Edgar
    Regioselective and controlled-density branching in amylose esters
    Carbohydrate Polymers
    332
    121885
    (2024)
    10.1016/j.carbpol.2024.121885
  • L. B. Giron, Q. Liu, O. S. Adeniji, X. Yin, T. Kannan, J. Ding, D. Y. Lu, S. Langan, J. Zhang, J. L. L. C. Azevedo, S. H. Li, S. Shalygin, P. Azadi, D. B. Hanna, I. Ofotokun, J. Lazar, M. A. Fischl, S. Haberlen, B. Macatangay, A. A. Adimora, B. D. Jamieson, C. Rinaldo, D. Merenstein, N. R. Roan, O. Kutsch, S. Gange, S. M. Wolinsky, M. D. Witt, W. S. Post, A. Kossenkov, A. L. Landay, I. Frank, P. C. Tien, R. Gross, T. T. Brown, and M. Abdel-Mohsen
    Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection
    Nature Communications
    15
    (2024)
    10.1038/s41467-024-47279-4
  • P. He, Y. Song, W. Jin, Y. Li, K. Xia, S. B. Kim, R. Dwivedi, M. Farrag, J. Bates, V. H. Pomin, C. Wang, R. J. Linhardt, J. S. Dordick, and F. Zhang
    Marine sulfated glycans inhibit the interaction of heparin with S-protein of SARS-CoV-2 Omicron XBB variant
    Glycoconjugate Journal
    41
    163-174
    (2024)
    10.1007/s10719-024-10150-1
  • Z. Zhai, and K. J. Edgar
    Polysaccharide Aldehydes and Ketones: Synthesis and Reactivity
    Biomacromolecules
    25
    2261-2276
    (2024)
    10.1021/acs.biomac.4c00020
  • C. Sarasa-Buisan, M. Nieves-Morión, S. Arévalo, R. F. Helm, E. Sevilla, I. Luque, and M. F. Fillat
    FurC (PerR) contributes to the regulation of peptidoglycan remodeling and intercellular molecular transfer in the cyanobacterium Anabaena sp. strain PCC 7120
    mBio
    15
    (2024)
    10.1128/mbio.03231-23
  • L. De los Santos, R. L. Beckman, C. DeBarro, J. E. Keener, M. D. T. Torres, C. D. L. Fuente-Nunez, J. S. Brodbelt, and R. M. Fleeman
    Polyproline peptide targets Klebsiella pneumoniae polysaccharides to collapse biofilms
    Cell Reports Physical Science
    5
    101869
    (2024)
    10.1016/j.xcrp.2024.101869
  • M. Cao, X. Bian, Z. Ji, M. Sohail, F. Zhang, R. J. Linhardt, B. Li, and X. Zhang
    Heparin Specifically Inhibits CRISPR/Cas12 Activation, Enabling Ultrasensitive Heparin Detection and Gene Editing Regulation
    Analytical Chemistry
    96
    3970-3978
    (2024)
    10.1021/acs.analchem.4c00403
  • J. Yang, Y. Song, W. Jin, K. Xia, G. C. Burnett, W. Qiao, J. T. Bates, V. H. Pomin, C. Wang, M. Qiao, R. J. Linhardt, J. S. Dordick, and F. Zhang
    Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin
    Viruses
    16
    237
    (2024)
    10.3390/v16020237
  • J. Zhang, P. Srivatsa, F. H. Ahmadzai, Y. Liu, X. Song, A. Karpatne, Z. (. Kong, and B. N. Johnson
    Improving biosensor accuracy and speed using dynamic signal change and theory-guided deep learning
    Biosensors and Bioelectronics
    246
    115829
    (2024)
    10.1016/j.bios.2023.115829
  • P. M. Datar, S. Y. Joshi, S. A. Deshmukh, and E. N. G. Marsh
    Probing the role of protein conformational changes in the mechanism of prenylated-FMN-dependent phenazine-1-carboxylic acid decarboxylase
    Journal of Biological Chemistry
    300
    105621
    (2024)
    10.1016/j.jbc.2023.105621
  • C. Gao, S. P. Petrova, and K. J. Edgar
    Chlorination of hydroxyethyl cellulose enables selective functionalization
    Cellulose
    31
    1481-1495
    (2024)
    10.1007/s10570-023-05675-x
  • A. F. Chinn, I. Trindade Coutinho, S. R. Kethireddy, N. R. Williams, K. M. Knott, R. B. Moore, and J. B. Matson
    Ethyl cellulose-block-poly(benzyl glutamate) block copolymer compatibilizers for ethyl cellulose/poly(ethylene terephthalate) blends
    Polymer Chemistry
    15
    3501-3509
    (2024)
    10.1039/d4py00688g
  • A. Chernykh, J. L. Abrahams, O. C. Grant, L. Kambanis, Z. Sumer-Bayraktar, J. Ugonotti, R. Kawahara, L. Corcilius, R. J. Payne, R. J. Woods, and M. Thaysen-Andersen
    Position-specific N- and O-glycosylation of the reactive center loop impacts neutrophil elastase–mediated proteolysis of corticosteroid-binding globulin
    Journal of Biological Chemistry
    300
    105519
    (2024)
    10.1016/j.jbc.2023.105519
  • W. Sun, I. Hafez, B. J. W. Cole, and M. Tajvidi
    A closer examination of white-rot fungal mycelia assisted wood bonding
    RSC Applied Interfaces
    1
    1036-1044
    (2024)
    10.1039/d4lf00061g
  • J. B. Matson, A. Q. Steele, J. D. Mase, and M. D. Schulz
    Polymer characterization by size-exclusion chromatography with multi-angle light scattering (SEC-MALS): a tutorial review
    Polymer Chemistry
    15
    127-142
    (2024)
    10.1039/d3py01181j
  • B. M. Shumberger, E. H. Fink, R. A. King, and T. D. Crawford
    On the use of property-oriented basis sets for the simulation of vibrational chiroptical spectroscopies
    Molecular Physics
    122
    (2023)
    10.1080/00268976.2023.2293232
  • K. A. King, A. H. Benton, M. T. Caudill, S. T. Stoyanof, L. Kang, P. Michalak, K. K. Lahmers, P. M. Dunman, T. G. DeHart, S. S. Ahmad, B. L. Jutras, K. Poncin, X. De Bolle, and C. C. Caswell
    Post‐transcriptional control of the essential enzyme MurF by a small regulatory RNA in Brucella abortus
    Molecular Microbiology
    121
    129-141
    (2023)
    10.1111/mmi.15207
  • D. Shi, H. Zhao, C. Bu, K. Fraser, H. Wang, J. S. Dordick, R. J. Linhardt, F. Zhang, F. Shi, and L. Chi
    New insights into the binding of PF4 to long heparin oligosaccharides in ultralarge complexes using mass spectrometry
    Journal of Thrombosis and Haemostasis
    21
    3608-3618
    (2023)
    10.1016/j.jtha.2023.08.020
  • E. Stancanelli, W. Liu, G. Su, V. Padagala, and J. Liu
    Developing a solid-phase method for the enzymatic synthesis of heparan sulfate and chondroitin sulfate backbones
    Glycobiology
    34
    (2023)
    10.1093/glycob/cwad093
  • W. R. Archer, T. Chen, V. Vaissier Welborn, and M. D. Schulz
    Polymer Tacticity Effects in Polymer–Lanthanide Chelation Thermodynamics
    Macromolecules
    56
    9062-9069
    (2023)
    10.1021/acs.macromol.3c01163
  • N. de Haan, M. Song, O. C. Grant, Z. Ye, F. Khoder Agha, M. Koed Møller Aasted, R. J. Woods, S. Y. Vakhrushev, and H. H. Wandall
    Sensitive and Specific Global Cell Surface N-Glycoproteomics Shows Profound Differences Between Glycosylation Sites and Subcellular Components
    Analytical Chemistry
    95
    17328-17336
    (2023)
    10.1021/acs.analchem.3c03626
  • J. Zhang, P. Srivatsa, F. H. Ahmadzai, Y. Liu, X. Song, A. Karpatne, Z. Kong, and B. N. Johnson
    Reduction of Biosensor False Responses and Time Delay Using Dynamic Response and Theory-Guided Machine Learning
    ACS Sensors
    8
    4079-4090
    (2023)
    10.1021/acssensors.3c01258
  • Y. Liu, J. Zhang, Y. Zhang, H. Y. Yoon, X. Jia, M. Roman, and B. N. Johnson
    Accelerated Engineering of Optimized Functional Composite Hydrogels via High-Throughput Experimentation
    ACS Applied Materials & Interfaces
    (2023)
    10.1021/acsami.3c11483
  • S. D. George, E. Andraos, T. Priemel, N. Horbelt, G. Keiser, A. Kumar, C. Heiss, N. Gierlinger, P. Azadi, and M. J. Harrington
    Structure, Function, and Application of Self‐Healing Adhesives from Mistletoe Viscin
    Advanced Functional Materials
    34
    (2023)
    10.1002/adfm.202307955
  • S. K. Singh, K. King, C. Gannett, C. Chuong, S. Y. Joshi, C. Plate, P. Farzeen, E. M. Webb, L. K. Kunche, J. Weger-Lucarelli, A. N. Lowell, A. M. Brown, and S. A. Deshmukh
    Data Driven Computational Design and Experimental Validation of Drugs for Accelerated Mitigation of Pandemic-like Scenarios
    The Journal of Physical Chemistry Letters
    14
    9490-9499
    (2023)
    10.1021/acs.jpclett.3c01749
  • S. K. Singh, A. T. Sose, F. Wang, K. K. Bejagam, and S. A. Deshmukh
    Data Driven Discovery of MOFs for Hydrogen Gas Adsorption
    Journal of Chemical Theory and Computation
    19
    6686-6703
    (2023)
    10.1021/acs.jctc.3c00081
  • Q. Zhang, W. Tang, E. Stancanelli, E. Jung, Z. Syed, V. Pagadala, L. Saidi, C. Z. Chen, P. Gao, M. Xu, I. Pavlinov, B. Li, W. Huang, L. Chen, J. Liu, H. Xie, W. Zheng, and Y. Ye
    Host heparan sulfate promotes ACE2 super-cluster assembly and enhances SARS-CoV-2-associated syncytium formation
    Nature Communications
    14
    (2023)
    10.1038/s41467-023-41453-w
  • A. Poulhazan, A. Baer, G. Daliaho, F. Mentink-Vigier, A. A. Arnold, D. C. Browne, L. Hering, S. Archer-Hartmann, L. E. Pepi, P. Azadi, S. Schmidt, G. Mayer, I. Marcotte, and M. J. Harrington
    Peculiar Phosphonate Modifications of Velvet Worm Slime Revealed by Advanced Nuclear Magnetic Resonance and Mass Spectrometry
    Journal of the American Chemical Society
    145
    20749-20754
    (2023)
    10.1021/jacs.3c06798
  • A. R. Cerullo, M. B. McDermott, L. E. Pepi, Z. Liu, D. Barry, S. Zhang, X. Yang, X. Chen, P. Azadi, M. Holford, and A. B. Braunschweig
    Comparative mucomic analysis of three functionally distinct Cornu aspersum Secretions
    Nature Communications
    14
    (2023)
    10.1038/s41467-023-41094-z
  • E. Hoffman, Y. Song, F. Zhang, L. Asarian, I. Downs, B. Young, X. Han, Y. Ouyang, K. Xia, R. J. Linhardt, and D. J. Weiss
    Regional and disease-specific glycosaminoglycan composition and function in decellularized human lung extracellular matrix
    Acta Biomaterialia
    168
    388-399
    (2023)
    10.1016/j.actbio.2023.06.043
  • M. M. Rahman, I. Hafez, M. Tajvidi, and A. Amirbahman
    Fundamentals of Hybrid Cellulose Nanofibril Foam Production by Microwave-Assisted Thawing/Drying Mechanism
    ACS Sustainable Chemistry & Engineering
    11
    13240-13250
    (2023)
    10.1021/acssuschemeng.3c00599
  • X. Ni, N. B. Murray, S. Archer-Hartmann, L. E. Pepi, R. F. Helm, P. Azadi, and P. Hong
    Toward Automatic Inference of Glycan Linkages Using MSn and Machine Learning─Proof of Concept Using Sialic Acid Linkages
    Journal of the American Society for Mass Spectrometry
    34
    2127-2135
    (2023)
    10.1021/jasms.3c00132
  • P. A. Miguez, E. Bash, M. L. Musskopf, S. A. Tuin, A. Rivera‐Concepcion, I. L. C. Chapple, and J. Liu
    Control of tissue homeostasis by the extracellular matrix: Synthetic heparan sulfate as a promising therapeutic for periodontal health and bone regeneration
    Periodontology 2000
    94
    510-531
    (2023)
    10.1111/prd.12515
  • E. Mohammadi, S. Y. Joshi, and S. A. Deshmukh
    Development, Validation, and Applications of Nonbonded Interaction Parameters between Coarse-Grained Amino Acid and Water Models
    Biomacromolecules
    24
    4078-4092
    (2023)
    10.1021/acs.biomac.3c00441
  • P. He, K. Xia, Y. Song, R. Tandon, R. Channappanavar, F. Zhang, and R. J. Linhardt
    Synthesis of multivalent sialyllactose-conjugated PAMAM dendrimers: Binding to SARS-CoV-2 spike protein and influenza hemagglutinin
    International Journal of Biological Macromolecules
    246
    125714
    (2023)
    10.1016/j.ijbiomac.2023.125714
  • W. Zhang, Y. Xu, X. Wang, T. Oikawa, G. Su, E. Wauthier, G. Wu, P. Sethupathy, Z. He, J. Liu, and L. M. Reid
    Fibrolamellar carcinomas–growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides
    Matrix Biology
    121
    194-216
    (2023)
    10.1016/j.matbio.2023.06.008
  • Y. Xiao, and R. J. Woods
    Protein–Ligand CH−π Interactions: Structural Informatics, Energy Function Development, and Docking Implementation
    Journal of Chemical Theory and Computation
    19
    5503-5515
    (2023)
    10.1021/acs.jctc.3c00300
  • Y. Song, A. Kouta, L. M. Cera, K. Xia, F. Zhang, R. Kraemer, J. Fareed, R. J. Linhardt, and W. Jeske
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    Carbohydrate Polymers
    311
    120779
    (2023)
    10.1016/j.carbpol.2023.120779
  • A. Shajahan, L. E. Pepi, B. Kumar, N. B. Murray, and P. Azadi
    Site specific N- and O-glycosylation mapping of the spike proteins of SARS-CoV-2 variants of concern
    Scientific Reports
    13
    (2023)
    10.1038/s41598-023-33088-0
  • R. Dwivedi, M. Farrag, P. Sharma, D. Shi, A. A. Shami, S. K. Misra, P. Ray, J. Shukla, F. Zhang, R. J. Linhardt, J. S. Sharp, R. Tandon, and V. H. Pomin
    The Sea Cucumber Thyonella gemmata Contains a Low Anticoagulant Sulfated Fucan with High Anti-SARS-CoV-2 Actions against Wild-Type and Delta Variants
    Journal of Natural Products
    86
    1463-1475
    (2023)
    10.1021/acs.jnatprod.3c00151
  • R. O. Rocha, R. S. Hussey, L. E. Pepi, P. Azadi, and M. Mitchum
    Discovery of Novel Effector Protein Candidates Produced in the Dorsal Gland of Adult Female Root-Knot Nematodes
    Molecular Plant-Microbe Interactions®
    36
    372-380
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    10.1094/mpmi-11-22-0232-r
  • Z. Zhai, Y. Zhou, A. G. Korovich, B. A. Hall, H. Y. Yoon, Y. Yao, J. Zhang, M. J. Bortner, M. Roman, L. A. Madsen, and K. J. Edgar
    Synthesis and Characterization of Multi-Reducing-End Polysaccharides
    Biomacromolecules
    24
    2596-2605
    (2023)
    10.1021/acs.biomac.3c00104
  • Z. Wang, V. N. Patel, X. Song, Y. Xu, A. M. Kaminski, V. U. Doan, G. Su, Y. Liao, D. Mah, F. Zhang, V. Pagadala, C. Wang, L. C. Pedersen, L. Wang, M. P. Hoffman, M. Gearing, and J. Liu
    Increased 3- O -sulfated heparan sulfate in Alzheimer’s disease brain is associated with genetic risk gene HS3ST1
    Science Advances
    9
    (2023)
    10.1126/sciadv.adf6232
  • S. J. Scannelli, A. Paripati, J. R. Weaver, C. Vu, M. Alaboalirat, D. Troya, and J. B. Matson
    Influence of the Norbornene Anchor Group in Ru-Mediated Ring-Opening Metathesis Polymerization: Synthesis of Linear Polymers
    Macromolecules
    56
    3848-3856
    (2023)
    10.1021/acs.macromol.3c00172
  • M. G. Wuo, A. E. Dugan, M. Halim, B. M. Hauser, J. Feldman, T. M. Caradonna, S. Zhang, L. E. Pepi, C. Atyeo, S. Fischinger, G. Alter, W. F. Garcia-Beltran, P. Azadi, D. Hung, A. G. Schmidt, and L. L. Kiessling
    Lectin Fingerprinting Distinguishes Antibody Neutralization in SARS-CoV-2
    ACS Central Science
    9
    947-956
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    10.1021/acscentsci.2c01471
  • W. Zhang, N. Wu, H. Wang, G. Mao, X. Yan, F. Zhang, R. J. Linhardt, W. Jin, and J. Zhou
    Sulfated fuco-manno-glucuronogalactan alleviates pancreatic beta cell senescence via PI3K/AKT/FoxO1 pathway
    International Journal of Biological Macromolecules
    236
    123846
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    10.1016/j.ijbiomac.2023.123846
  • D. Shi, P. He, Y. Song, R. J. Linhardt, J. S. Dordick, L. Chi, and F. Zhang
    Interactions of heparin with key glycoproteins of human respiratory syncytial virus
    Frontiers in Molecular Biosciences
    10
    (2023)
    10.3389/fmolb.2023.1151174
  • D. Al Mahbuba, S. Masuko, S. Wang, D. Syangtan, J. S. Kang, Y. Song, T. W. Shin, K. Xia, F. Zhang, R. J. Linhardt, E. S. Boyden, and L. L. Kiessling
    Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation
    ACS Nano
    17
    7207-7218
    (2023)
    10.1021/acsnano.2c10072
  • P. S. Kwon, S. Xu, H. Oh, S. Kwon, A. L. Rodrigues, M. Feroz, K. Fraser, P. He, F. Zhang, J. J. Hong, R. J. Linhardt, and J. S. Dordick
    Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactions
    Communications Biology
    6
    (2023)
    10.1038/s42003-023-04789-z
  • J. Zheng, H. Xu, B. Li, M. Sohail, J. Bi, F. Zhang, R. J. Linhardt, H. Huang, and X. Zhang
    Spatially Segregated MOF Bioreactor Enables Versatile Modular Glycoenzyme Assembly for Hierarchical Glycan Library Construction
    ACS Applied Materials & Interfaces
    15
    19807-19816
    (2023)
    10.1021/acsami.2c22094
  • E. Kucukdeger, and B. N. Johnson
    Closed-loop controlled conformal 3D printing on moving objects via tool-localized object position sensing
    Journal of Manufacturing Processes
    89
    39-49
    (2023)
    10.1016/j.jmapro.2023.01.020
  • B. M. Knight, K. J. Edgar, J. J. De Yoreo, and P. M. Dove
    Chitosan as a Canvas for Studies of Macromolecular Controls on CaCO3Biological Crystallization
    Biomacromolecules
    24
    1078-1102
    (2023)
    10.1021/acs.biomac.2c01394
  • J. Zhang, Y. Liu, D. Chandra Sekhar.P, M. Singh, Y. Tong, E. Kucukdeger, H. Y. Yoon, A. P. Haring, M. Roman, Z. (. Kong, and B. N. Johnson
    Rapid, autonomous high-throughput characterization of hydrogel rheological properties via automated sensing and physics-guided machine learning
    Applied Materials Today
    30
    101720
    (2023)
    10.1016/j.apmt.2022.101720
  • G. Yu, G. Liu, T. Liu, E. H. Fink, and A. R. Esker
    Activities of Family 18 Chitinases on Amorphous Regenerated Chitin Thin Films and Dissolved Chitin Oligosaccharides: Comparison with Family 19 Chitinases
    Biomacromolecules
    24
    566-575
    (2023)
    10.1021/acs.biomac.2c00538
  • Y. Wang, S. Chen, G. Chen, E. Shurberg, H. Liu, and P. Hong
    Motif-Based Graph Representation Learning with Application to Chemical Molecules
    Informatics
    10
    8
    (2023)
    10.3390/informatics10010008
  • S. J. Scannelli, M. Alaboalirat, D. Troya, and J. B. Matson
    Ring-opening metathesis polymerization of norbornene–benzoladderene (macro)monomers
    Polymer Chemistry
    14
    4726-4735
    (2023)
    10.1039/d3py00981e
  • A. T. Sose, S. Y. Joshi, L. K. Kunche, F. Wang, and S. A. Deshmukh
    A review of recent advances and applications of machine learning in tribology
    Physical Chemistry Chemical Physics
    25
    4408-4443
    (2023)
    10.1039/d2cp03692d
  • W. Jin, C. Lu, Y. Zhu, J. Zhao, W. Zhang, L. Wang, R. J. Linhardt, C. Wang, and F. Zhang
    Fucoidans inhibited tau interaction and cellular uptake
    Carbohydrate Polymers
    299
    120176
    (2023)
    10.1016/j.carbpol.2022.120176
  • F. Eilts, S. Bauer, K. Fraser, J. S. Dordick, M. W. Wolff, R. J. Linhardt, and F. Zhang
    The diverse role of heparan sulfate and other GAGs in SARS-CoV-2 infections and therapeutics
    Carbohydrate Polymers
    299
    120167
    (2023)
    10.1016/j.carbpol.2022.120167
  • V. Vaissier Welborn, W. R. Archer, and M. D. Schulz
    Characterizing Ion-Polymer Interactions in Aqueous Environment with Electric Fields
    Journal of Chemical Information and Modeling
    63
    2030-2036
    (2022)
    10.1021/acs.jcim.2c01048
  • P. He, X. Zhang, K. Xia, D. E. Green, S. Baytas, Y. Xu, T. Pham, J. Liu, F. Zhang, A. Almond, R. J. Linhardt, and P. L. DeAngelis
    Chemoenzymatic synthesis of sulfur-linked sugar polymers as heparanase inhibitors
    Nature Communications
    13
    (2022)
    10.1038/s41467-022-34788-3
  • D. Shi, C. Bu, P. He, Y. Song, J. S. Dordick, R. J. Linhardt, L. Chi, and F. Zhang
    Structural Characteristics of Heparin Binding to SARS-CoV-2 Spike Protein RBD of Omicron Sub-Lineages BA.2.12.1, BA.4 and BA.5
    Viruses
    14
    2696
    (2022)
    10.3390/v14122696
  • B. N. Johnson
    A sweet solution to complex microprinting
    Science
    378
    826-827
    (2022)
    10.1126/science.ade6722
  • P. Wang, L. Chi, Z. Zhang, H. Zhao, F. Zhang, and R. J. Linhardt
    Heparin: An old drug for new clinical applications
    Carbohydrate Polymers
    295
    119818
    (2022)
    10.1016/j.carbpol.2022.119818
  • Y. Yu, L. Fu, P. He, K. Xia, S. Varghese, J. Dordick, H. Wang, F. Zhang, and R. J. Linhardt
    Enzymatic synthesis of low molecular weight heparins from N-sulfo heparosan depolymerized by heparanase or heparin lyase
    Carbohydrate Polymers
    295
    119825
    (2022)
    10.1016/j.carbpol.2022.119825
  • J. Zhang, L. Liang, W. Yang, S. Ramadan, K. Baryal, C. Huo, J. J. Bernard, J. Liu, L. Hsieh‐Wilson, F. Zhang, R. J. Linhardt, and X. Huang
    Expedient Synthesis of a Library of Heparan Sulfate‐Like “Head‐to‐Tail” Linked Multimers for Structure and Activity Relationship Studies**
    Angewandte Chemie International Edition
    61
    (2022)
    10.1002/anie.202209730
  • K. Arnold, Z. Wang, A. Lucas, W. Zamboni, Y. Xu, and J. Liu
    Investigation of the pharmacokinetic properties of synthetic heparan sulfate oligosaccharides
    Glycobiology
    33
    104-114
    (2022)
    10.1093/glycob/cwac068
  • X. Wang, M. S. Hanes, R. D. Cummings, and R. J. Woods
    Computationally guided conversion of the specificity of E-selectin to mimic that of Siglec-8
    Proceedings of the National Academy of Sciences
    119
    (2022)
    10.1073/pnas.2117743119
  • D. Shi, A. Sheng, C. Bu, Z. An, X. Cui, X. Sun, H. Li, F. Zhang, R. J. Linhardt, T. Zhang, L. Jin, and L. Chi
    A Cluster Sequencing Strategy To Determine the Consensus Affinity Domains in Heparin for Its Binding to Specific Proteins
    Analytical Chemistry
    94
    13987-13994
    (2022)
    10.1021/acs.analchem.2c03267
  • P. He, S. Faris, R. S. Sagabala, P. Datta, Z. Xu, B. Callahan, C. Wang, B. Boivin, F. Zhang, and R. J. Linhardt
    Cholesterol Chip for the Study of Cholesterol–Protein Interactions Using SPR
    Biosensors
    12
    788
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    10.3390/bios12100788
  • R. Dwivedi, P. Sharma, F. Eilts, F. Zhang, R. J. Linhardt, R. Tandon, and V. H. Pomin
    Anti-SARS-CoV-2 and anticoagulant properties of Pentacta pygmaea fucosylated chondroitin sulfate depend on high molecular weight structures
    Glycobiology
    33
    75-85
    (2022)
    10.1093/glycob/cwac063
  • W. Zhang, W. Jin, V. H. Pomin, F. Zhang, and R. J. Linhardt
    Interactions of marine sulfated glycans with antithrombin and platelet factor 4
    Frontiers in Molecular Biosciences
    9
    (2022)
    10.3389/fmolb.2022.954752
  • D. Shi, P. He, Y. Song, S. Cheng, R. J. Linhardt, J. S. Dordick, L. Chi, and F. Zhang
    Kinetic and Structural Aspects of Glycosaminoglycan–Monkeypox Virus Protein A29 Interactions Using Surface Plasmon Resonance
    Molecules
    27
    5898
    (2022)
    10.3390/molecules27185898
  • A. L. Gelbach, F. Zhang, S. Kwon, J. T. Bates, A. P. Farmer, J. S. Dordick, C. Wang, and R. J. Linhardt
    Interactions between heparin and SARS-CoV-2 spike glycoprotein RBD from omicron and other variants
    Frontiers in Molecular Biosciences
    9
    (2022)
    10.3389/fmolb.2022.912887
  • B. Subramaniam, N. Leonick, V. Gade, D. M. Frey, F. Zhang, R. J. Linhardt, and R. A. Gross
    Ionically Complexed Nanoparticles for Heparin Oral Delivery
    Precision Nanomedicine
    5
    (2022)
    10.33218/001c.37505
  • C. Yanucil, D. Kentrup, I. Campos, B. Czaya, K. Heitman, D. Westbrook, G. Osis, A. Grabner, A. R. Wende, J. Vallejo, M. J. Wacker, J. A. Navarro-Garcia, G. Ruiz-Hurtado, F. Zhang, Y. Song, R. J. Linhardt, K. White, M. S. Kapiloff, and C. Faul
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    Kidney International
    102
    261-279
    (2022)
    10.1016/j.kint.2022.03.028
  • Y. Liu, K. Bethel, M. Singh, J. Zhang, R. Ashkar, E. M. Davis, and B. N. Johnson
    Comparison of Bulk- vs Layer-by-Layer-Cured Stimuli-Responsive PNIPAM–Alginate Hydrogel Dynamic Viscoelastic Property Response via Embedded Sensors
    ACS Applied Polymer Materials
    4
    5596-5607
    (2022)
    10.1021/acsapm.2c00634
  • J. J. Erickson, S. Archer-Hartmann, A. E. Yarawsky, J. L. C. Miller, S. Seveau, T. Shao, A. L. Severance, H. Miller-Handley, Y. Wu, G. Pham, B. R. Wasik, C. R. Parrish, Y. Hu, J. T. Y. Lau, P. Azadi, A. B. Herr, and S. S. Way
    Pregnancy enables antibody protection against intracellular infection
    Nature
    606
    769-775
    (2022)
    10.1038/s41586-022-04816-9
  • G. Kaur, Y. Song, K. Xia, K. McCarthy, F. Zhang, R. J. Linhardt, and N. R. Harris
    Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retina
    Glycobiology
    32
    720-734
    (2022)
    10.1093/glycob/cwac029
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    Knowledgebra: An Algebraic Learning Framework for Knowledge Graph
    Machine Learning and Knowledge Extraction
    4
    432-445
    (2022)
    10.3390/make4020019
  • S. B. Kim, M. Zoepfl, P. Samanta, F. Zhang, K. Xia, R. Thara, R. J. Linhardt, R. J. Doerksen, M. A. McVoy, and V. H. Pomin
    Fractionation of sulfated galactan from the red alga Botryocladia occidentalis separates its anticoagulant and anti-SARS-CoV-2 properties
    Journal of Biological Chemistry
    298
    101856
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    10.1016/j.jbc.2022.101856
  • E. Stancanelli, W. Liu, R. Wander, J. Li, Z. Wang, K. Arnold, G. Su, A. Kanack, T. Q. Pham, V. Pagadala, A. Padmanabhan, Y. Xu, and J. Liu
    Chemoenzymatic Synthesis of Homogeneous Heparan Sulfate and Chondroitin Sulfate Chimeras
    ACS Chemical Biology
    17
    1207-1214
    (2022)
    10.1021/acschembio.2c00146
  • E. Ahat, Y. Song, K. Xia, W. Reid, J. Li, S. Bui, F. Zhang, R. J. Linhardt, and Y. Wang
    GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion
    Cellular and Molecular Life Sciences
    79
    (2022)
    10.1007/s00018-022-04223-3
  • S. Y. Joshi, S. Singh, and S. A. Deshmukh
    Coarse-grained molecular dynamics integrated with convolutional neural network for comparing shapes of temperature sensitive bottlebrushes
    npj Computational Materials
    8
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    10.1038/s41524-022-00725-7
  • Y. Yu, L. Fu, P. He, K. Xia, S. Varghese, H. Wang, F. Zhang, J. Dordick, and R. J. Linhardt
    Chemobiocatalytic Synthesis of a Low-Molecular-Weight Heparin
    ACS Chemical Biology
    17
    637-646
    (2022)
    10.1021/acschembio.1c00928
  • F. Zhang, P. He, A. L. Rodrigues, W. Jeske, R. Tandon, J. T. Bates, M. A. Bierdeman, J. Fareed, J. Dordick, and R. J. Linhardt
    Potential Anti-SARS-CoV-2 Activity of Pentosan Polysulfate and Mucopolysaccharide Polysulfate
    Pharmaceuticals
    15
    258
    (2022)
    10.3390/ph15020258
  • W. R. Archer, G. E. Dinges, P. L. MacNicol, and M. D. Schulz
    Synthesis of bottlebrush polymers based on poly(N-sulfonyl aziridine) macromonomers
    Polymer Chemistry
    13
    6134-6139
    (2022)
    10.1039/d2py01125e
  • X. Cao, S. Wang, M. R. Gadi, D. Liu, P. G. Wang, X. Wan, J. Zhang, X. Chen, L. E. Pepi, P. Azadi, and L. Li
    Systematic synthesis of bisected N-glycans and unique recognitions by glycan-binding proteins
    Chemical Science
    13
    7644-7656
    (2022)
    10.1039/d1sc05435j
  • R. Wander, A. M. Kaminski, Z. Wang, E. Stancanelli, Y. Xu, V. Pagadala, J. Li, J. M. Krahn, T. Q. Pham, J. Liu, and L. C. Pedersen
    Structural and Substrate Specificity Analysis of 3-O-Sulfotransferase Isoform 5 to Synthesize Heparan Sulfate
    ACS Catalysis
    11
    14956-14966
    (2021)
    10.1021/acscatal.1c04520
  • Y. Song, P. He, A. L. Rodrigues, P. Datta, R. Tandon, J. T. Bates, M. A. Bierdeman, C. Chen, J. Dordick, F. Zhang, and R. J. Linhardt
    Anti-SARS-CoV-2 Activity of Rhamnan Sulfate from Monostroma nitidum
    Marine Drugs
    19
    685
    (2021)
    10.3390/md19120685
  • T. G. DeHart, M. R. Kushelman, S. B. Hildreth, R. F. Helm, and B. L. Jutras
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    Nature Microbiology
    6
    1583-1592
    (2021)
    10.1038/s41564-021-01003-w
  • E. Mohammadi, S. Y. Joshi, and S. A. Deshmukh
    A review of computational studies of bottlebrush polymers
    Computational Materials Science
    199
    110720
    (2021)
    10.1016/j.commatsci.2021.110720
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    Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection
    Journal of Biological Chemistry
    297
    101207
    (2021)
    10.1016/j.jbc.2021.101207
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    Professor
    Complex Carbohydrate Research Center
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    Associate Professor
    Department of Biochemistry
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    Senior Research Scientist
    Department of Biochemistry and Molecular Biology
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    Fralin Life Sciences Institute
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