GlycoMIP
GlycoMIP is an NSF-funded national user facility and multidisciplinary research program that addresses scientific and technological bottlenecks in glycomaterials research. A partnership between Virginia Tech, the University of Georgia, Brandeis University, and Rensselaer Polytechnic Institute, GlycoMIP accelerates glycomaterials discovery and development through leading-edge research and a state-of-the-art user facility.
Publications
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Analytic Computation of Vibrational Circular Dichroism Spectra Using Second-Order Møller–Plesset Perturbation TheoryJournal of Chemical Theory and Computation213504-3512(2025)
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TransPeakNet for solvent-aware 2D NMR prediction via multi-task pre-training and unsupervised learningCommunications Chemistry8(2025)
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Increasing Glucose Yield from Cellulose in Ground Corn Using Plant-Made Recombinant CellulasesIndustrial Biotechnology2147-54(2025)
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Applying a polysaccharide lyase from Stenotrophomonas maltophilia to disrupt alginate exopolysaccharide produced by Pseudomonas aeruginosa clinical isolatesApplied and Environmental Microbiology91(2025)
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Entropy-enthalpy compensation in the methyl 5-thio-α-d-galactopyranoside–Jacalin interactionCarbohydrate Research547109305(2025)
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Scalable Accelerated Materials Discovery of Sustainable Polysaccharide-Based Hydrogels by Autonomous Experimentation and Collaborative LearningACS Applied Materials & Interfaces1670310-70321(2024)
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Inhibition of sulfated glycans on the binding of dengue virus envelope protein to heparinGlycoconjugate Journal41371-380(2024)
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Electric Fields in Polymeric SystemsChemical Reviews12413331-13369(2024)
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Systematic Evaluation of Macromolecular Carbohydrate-Lectin Recognition Using Precision GlycopolymersBiomacromolecules257985-7994(2024)
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Overview of Glycosylation Studies of SARS-CoV-2Glycoprotein Analysis1-28(2024)
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Silica–Biomacromolecule Interactions: Toward a Mechanistic Understanding of SilicificationBiomacromolecules2643-84(2024)
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Nanopore-regulated in situ polymerization for synthesis of homogeneous heparan sulfate with low dispersityCarbohydrate Polymers341122297(2024)
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A naturally derived biomaterial formulation for improved menstrual careMatter72941-2958(2024)
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Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylationMolecular Therapy - Methods & Clinical Development32101301(2024)
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Quality control, safety assessment and preparation approaches of low molecular weight heparinCarbohydrate Polymers339122216(2024)
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TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acidJournal of Biological Chemistry300107691(2024)
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Stimuli-Responsive Polymers at the Interface with BiologyBiomacromolecules255417-5436(2024)
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Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viabilityProceedings of the National Academy of Sciences121(2024)
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Synthesis and real-time characterization of self-healing, injectable, fast-gelling hydrogels based on alginate multi-reducing end polysaccharides (MREPs)Carbohydrate Polymers338122172(2024)
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Seaweed-derived fucoidans and rhamnan sulfates serve as potent anti-SARS-CoV-2 agents with potential for prophylaxisCarbohydrate Polymers337122156(2024)
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Kinetics of Calcite Nucleation onto Sulfated Chitosan Derivatives and Implications for Water–Polysaccharide Interactions during Crystallization of Sparingly Soluble SaltsCrystal Growth & Design246338-6353(2024)
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Effects of Copper on Legionella pneumophila Revealed via Viability Assays and ProteomicsPathogens13563(2024)
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All-polysaccharide, self-healing, pH-sensitive, in situ-forming hydrogel of carboxymethyl chitosan and aldehyde-functionalized hydroxyethyl celluloseCarbohydrate Polymers336122105(2024)
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Automated Characterization of Macroscale Tissue 3D Spatial Material Properties via Robotically-Directed Impedimetric SensingIEEE Transactions on Automation Science and Engineering213408-3420(2024)
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Graph–Graph Similarity NetworkIEEE Transactions on Neural Networks and Learning Systems359136-9146(2024)
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Evaluation of Sampling Algorithms Used for Bayesian Uncertainty Quantification of Molecular Dynamics Force FieldsJournal of Chemical Theory and Computation205732-5742(2024)
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Polysaccharide‐based
H2S donors: Thiol‐ene functionalization of amylopectin withH2S ‐releasingN ‐thiocarboxyanhydridesJournal of Polymer Science624155-4164(2024) -
Imbalanced spectral data analysis using data augmentation based on the generative adversarial networkScientific Reports14(2024)
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Structural and genetic basis for the binding of a mouse monoclonal antibody to Flavobacterium psychrophilum lipopolysaccharideJournal of Fish Diseases(2024)
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Predicting the stereoselectivity of chemical reactions by composite machine learning methodScientific Reports14(2024)
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Characterization of Ssc, an N -acetylgalactosamine-containing Staphylococcus aureus surface polysaccharideJournal of Bacteriology206(2024)
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Marine-Derived Sulfated Glycans Inhibit the Interaction of Heparin with Adhesion Proteins of Mycoplasma pneumoniaeMarine Drugs22232(2024)
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Regioselective and controlled-density branching in amylose estersCarbohydrate Polymers332121885(2024)
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Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infectionNature Communications15(2024)
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Marine sulfated glycans inhibit the interaction of heparin with S-protein of SARS-CoV-2 Omicron XBB variantGlycoconjugate Journal41163-174(2024)
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Polysaccharide Aldehydes and Ketones: Synthesis and ReactivityBiomacromolecules252261-2276(2024)
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FurC (PerR) contributes to the regulation of peptidoglycan remodeling and intercellular molecular transfer in the cyanobacterium Anabaena sp. strain PCC 7120mBio15(2024)
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Polyproline peptide targets Klebsiella pneumoniae polysaccharides to collapse biofilmsCell Reports Physical Science5101869(2024)
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Heparin Specifically Inhibits CRISPR/Cas12 Activation, Enabling Ultrasensitive Heparin Detection and Gene Editing RegulationAnalytical Chemistry963970-3978(2024)
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Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with HeparinViruses16237(2024)
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Improving biosensor accuracy and speed using dynamic signal change and theory-guided deep learningBiosensors and Bioelectronics246115829(2024)
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Probing the role of protein conformational changes in the mechanism of prenylated-FMN-dependent phenazine-1-carboxylic acid decarboxylaseJournal of Biological Chemistry300105621(2024)
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Chlorination of hydroxyethyl cellulose enables selective functionalizationCellulose311481-1495(2024)
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Ethyl cellulose-block-poly(benzyl glutamate) block copolymer compatibilizers for ethyl cellulose/poly(ethylene terephthalate) blendsPolymer Chemistry153501-3509(2024)
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Position-specific N- and O-glycosylation of the reactive center loop impacts neutrophil elastase–mediated proteolysis of corticosteroid-binding globulinJournal of Biological Chemistry300105519(2024)
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A closer examination of white-rot fungal mycelia assisted wood bondingRSC Applied Interfaces11036-1044(2024)
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Polymer characterization by size-exclusion chromatography with multi-angle light scattering (SEC-MALS): a tutorial reviewPolymer Chemistry15127-142(2024)
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On the use of property-oriented basis sets for the simulation of vibrational chiroptical spectroscopiesMolecular Physics122(2023)
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Post‐transcriptional control of the essential enzyme
MurF by a small regulatoryRNA in Brucella abortusMolecular Microbiology121129-141(2023) -
New insights into the binding of PF4 to long heparin oligosaccharides in ultralarge complexes using mass spectrometryJournal of Thrombosis and Haemostasis213608-3618(2023)
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Developing a solid-phase method for the enzymatic synthesis of heparan sulfate and chondroitin sulfate backbonesGlycobiology34(2023)
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Polymer Tacticity Effects in Polymer–Lanthanide Chelation ThermodynamicsMacromolecules569062-9069(2023)
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Sensitive and Specific Global Cell Surface N-Glycoproteomics Shows Profound Differences Between Glycosylation Sites and Subcellular ComponentsAnalytical Chemistry9517328-17336(2023)
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Reduction of Biosensor False Responses and Time Delay Using Dynamic Response and Theory-Guided Machine LearningACS Sensors84079-4090(2023)
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Accelerated Engineering of Optimized Functional Composite Hydrogels via High-Throughput ExperimentationACS Applied Materials & Interfaces(2023)
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Structure, Function, and Application of Self‐Healing Adhesives from Mistletoe ViscinAdvanced Functional Materials34(2023)
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Data Driven Computational Design and Experimental Validation of Drugs for Accelerated Mitigation of Pandemic-like ScenariosThe Journal of Physical Chemistry Letters149490-9499(2023)
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Data Driven Discovery of MOFs for Hydrogen Gas AdsorptionJournal of Chemical Theory and Computation196686-6703(2023)
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Host heparan sulfate promotes ACE2 super-cluster assembly and enhances SARS-CoV-2-associated syncytium formationNature Communications14(2023)
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Peculiar Phosphonate Modifications of Velvet Worm Slime Revealed by Advanced Nuclear Magnetic Resonance and Mass SpectrometryJournal of the American Chemical Society14520749-20754(2023)
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Comparative mucomic analysis of three functionally distinct Cornu aspersum SecretionsNature Communications14(2023)
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Regional and disease-specific glycosaminoglycan composition and function in decellularized human lung extracellular matrixActa Biomaterialia168388-399(2023)
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Fundamentals of Hybrid Cellulose Nanofibril Foam Production by Microwave-Assisted Thawing/Drying MechanismACS Sustainable Chemistry & Engineering1113240-13250(2023)
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Toward Automatic Inference of Glycan Linkages Using MSn and Machine Learning─Proof of Concept Using Sialic Acid LinkagesJournal of the American Society for Mass Spectrometry342127-2135(2023)
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Control of tissue homeostasis by the extracellular matrix: Synthetic heparan sulfate as a promising therapeutic for periodontal health and bone regenerationPeriodontology 200094510-531(2023)
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Development, Validation, and Applications of Nonbonded Interaction Parameters between Coarse-Grained Amino Acid and Water ModelsBiomacromolecules244078-4092(2023)
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Synthesis of multivalent sialyllactose-conjugated PAMAM dendrimers: Binding to SARS-CoV-2 spike protein and influenza hemagglutininInternational Journal of Biological Macromolecules246125714(2023)
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Fibrolamellar carcinomas–growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharidesMatrix Biology121194-216(2023)
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Protein–Ligand CH−π Interactions: Structural Informatics, Energy Function Development, and Docking ImplementationJournal of Chemical Theory and Computation195503-5515(2023)
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Absolute pharmacokinetics of heparin in primatesCarbohydrate Polymers311120779(2023)
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Site specific N- and O-glycosylation mapping of the spike proteins of SARS-CoV-2 variants of concernScientific Reports13(2023)
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The Sea Cucumber Thyonella gemmata Contains a Low Anticoagulant Sulfated Fucan with High Anti-SARS-CoV-2 Actions against Wild-Type and Delta VariantsJournal of Natural Products861463-1475(2023)
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Discovery of Novel Effector Protein Candidates Produced in the Dorsal Gland of Adult Female Root-Knot NematodesMolecular Plant-Microbe Interactions®36372-380(2023)
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Synthesis and Characterization of Multi-Reducing-End PolysaccharidesBiomacromolecules242596-2605(2023)
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Increased 3- O -sulfated heparan sulfate in Alzheimer’s disease brain is associated with genetic risk gene HS3ST1Science Advances9(2023)
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Influence of the Norbornene Anchor Group in Ru-Mediated Ring-Opening Metathesis Polymerization: Synthesis of Linear PolymersMacromolecules563848-3856(2023)
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Lectin Fingerprinting Distinguishes Antibody Neutralization in SARS-CoV-2ACS Central Science9947-956(2023)
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Sulfated fuco-manno-glucuronogalactan alleviates pancreatic beta cell senescence via PI3K/AKT/FoxO1 pathwayInternational Journal of Biological Macromolecules236123846(2023)
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Interactions of heparin with key glycoproteins of human respiratory syncytial virusFrontiers in Molecular Biosciences10(2023)
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Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell DifferentiationACS Nano177207-7218(2023)
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Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactionsCommunications Biology6(2023)
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Spatially Segregated MOF Bioreactor Enables Versatile Modular Glycoenzyme Assembly for Hierarchical Glycan Library ConstructionACS Applied Materials & Interfaces1519807-19816(2023)
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Closed-loop controlled conformal 3D printing on moving objects via tool-localized object position sensingJournal of Manufacturing Processes8939-49(2023)
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Chitosan as a Canvas for Studies of Macromolecular Controls on CaCO3Biological CrystallizationBiomacromolecules241078-1102(2023)
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Rapid, autonomous high-throughput characterization of hydrogel rheological properties via automated sensing and physics-guided machine learningApplied Materials Today30101720(2023)
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Activities of Family 18 Chitinases on Amorphous Regenerated Chitin Thin Films and Dissolved Chitin Oligosaccharides: Comparison with Family 19 ChitinasesBiomacromolecules24566-575(2023)
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Motif-Based Graph Representation Learning with Application to Chemical MoleculesInformatics108(2023)
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Ring-opening metathesis polymerization of norbornene–benzoladderene (macro)monomersPolymer Chemistry144726-4735(2023)
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A review of recent advances and applications of machine learning in tribologyPhysical Chemistry Chemical Physics254408-4443(2023)
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Fucoidans inhibited tau interaction and cellular uptakeCarbohydrate Polymers299120176(2023)
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The diverse role of heparan sulfate and other GAGs in SARS-CoV-2 infections and therapeuticsCarbohydrate Polymers299120167(2023)
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Characterizing Ion-Polymer Interactions in Aqueous Environment with Electric FieldsJournal of Chemical Information and Modeling632030-2036(2022)
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Chemoenzymatic synthesis of sulfur-linked sugar polymers as heparanase inhibitorsNature Communications13(2022)
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Structural Characteristics of Heparin Binding to SARS-CoV-2 Spike Protein RBD of Omicron Sub-Lineages BA.2.12.1, BA.4 and BA.5Viruses142696(2022)
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Heparin: An old drug for new clinical applicationsCarbohydrate Polymers295119818(2022)
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Enzymatic synthesis of low molecular weight heparins from N-sulfo heparosan depolymerized by heparanase or heparin lyaseCarbohydrate Polymers295119825(2022)
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Expedient Synthesis of a Library of Heparan Sulfate‐Like “Head‐to‐Tail” Linked Multimers for Structure and Activity Relationship Studies**Angewandte Chemie International Edition61(2022)
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Investigation of the pharmacokinetic properties of synthetic heparan sulfate oligosaccharidesGlycobiology33104-114(2022)
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Computationally guided conversion of the specificity of E-selectin to mimic that of Siglec-8Proceedings of the National Academy of Sciences119(2022)
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A Cluster Sequencing Strategy To Determine the Consensus Affinity Domains in Heparin for Its Binding to Specific ProteinsAnalytical Chemistry9413987-13994(2022)
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Cholesterol Chip for the Study of Cholesterol–Protein Interactions Using SPRBiosensors12788(2022)
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Anti-SARS-CoV-2 and anticoagulant properties of Pentacta pygmaea fucosylated chondroitin sulfate depend on high molecular weight structuresGlycobiology3375-85(2022)
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Interactions of marine sulfated glycans with antithrombin and platelet factor 4Frontiers in Molecular Biosciences9(2022)
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Kinetic and Structural Aspects of Glycosaminoglycan–Monkeypox Virus Protein A29 Interactions Using Surface Plasmon ResonanceMolecules275898(2022)
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Interactions between heparin and SARS-CoV-2 spike glycoprotein RBD from omicron and other variantsFrontiers in Molecular Biosciences9(2022)
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Ionically Complexed Nanoparticles for Heparin Oral DeliveryPrecision Nanomedicine5(2022)
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Soluble α-klotho and heparin modulate the pathologic cardiac actions of fibroblast growth factor 23 in chronic kidney diseaseKidney International102261-279(2022)
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Comparison of Bulk- vs Layer-by-Layer-Cured Stimuli-Responsive PNIPAM–Alginate Hydrogel Dynamic Viscoelastic Property Response via Embedded SensorsACS Applied Polymer Materials45596-5607(2022)
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Pregnancy enables antibody protection against intracellular infectionNature606769-775(2022)
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Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retinaGlycobiology32720-734(2022)
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Knowledgebra: An Algebraic Learning Framework for Knowledge GraphMachine Learning and Knowledge Extraction4432-445(2022)
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Fractionation of sulfated galactan from the red alga Botryocladia occidentalis separates its anticoagulant and anti-SARS-CoV-2 propertiesJournal of Biological Chemistry298101856(2022)
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Chemoenzymatic Synthesis of Homogeneous Heparan Sulfate and Chondroitin Sulfate ChimerasACS Chemical Biology171207-1214(2022)
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GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretionCellular and Molecular Life Sciences79(2022)
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Coarse-grained molecular dynamics integrated with convolutional neural network for comparing shapes of temperature sensitive bottlebrushesnpj Computational Materials8(2022)
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Chemobiocatalytic Synthesis of a Low-Molecular-Weight HeparinACS Chemical Biology17637-646(2022)
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Potential Anti-SARS-CoV-2 Activity of Pentosan Polysulfate and Mucopolysaccharide PolysulfatePharmaceuticals15258(2022)
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Synthesis of bottlebrush polymers based on poly(N-sulfonyl aziridine) macromonomersPolymer Chemistry136134-6139(2022)
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Systematic synthesis of bisected N-glycans and unique recognitions by glycan-binding proteinsChemical Science137644-7656(2022)
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Structural and Substrate Specificity Analysis of 3-O-Sulfotransferase Isoform 5 to Synthesize Heparan SulfateACS Catalysis1114956-14966(2021)
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Anti-SARS-CoV-2 Activity of Rhamnan Sulfate from Monostroma nitidumMarine Drugs19685(2021)
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The unusual cell wall of the Lyme disease spirochaete Borrelia burgdorferi is shaped by a tick sugarNature Microbiology61583-1592(2021)
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A review of computational studies of bottlebrush polymersComputational Materials Science199110720(2021)
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Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infectionJournal of Biological Chemistry297101207(2021)

People
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Maren RomanAssociate ProfessorDepartment of Sustainable Biomaterials
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Robert J. WoodsProfessorComplex Carbohydrate Research Center
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Richard HelmAssociate ProfessorDepartment of Biochemistry
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Parastoo AzadiSenior Research ScientistDepartment of Biochemistry and Molecular Biology
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Linda CaudillManaging DirectorFralin Life Sciences Institute
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Sanket DeshmukhAssistant ProfessorDepartment of Chemical Engineering
Universities



