Nanotemper Monolith Pico Microscale Thermophoresis (MST)


The Monolith MST is used to analyze the interactions between glycomaterials and biomolecules and is based on the detection of a temperature-induced change in fluorescence of a target as a function of the concentration of a non-fluorescent ligand. Unlike surface plasmon resonance (SPR), which immobilizes molecules often causing them to lose activity, the Monolith measures binding interaction in solution. Measuring Kds in solution allows both binding partners to freely interact in their native confirmation.

Learn more.

National Science Foundation

Division of Materials Research

2415 Eisenhower Avenue

Alexandria, VA 22314

Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.