Microelectron Diffraction (MicroED)


MicroED excels at detecting atomic periodicities smaller than 1 Å and ab initio determination of molecular structures at this scale. Better than ~0.8 Å periodicities can be determined in crystal too small to be analyzed using traditional x-ray techniques. MicroED structure solutions reveal all atoms in an assembly, even hydrogens and for semi-crystalline biopolymers, and regions of local order/disorder are revealed. Importantly, in the best of cases, these structures can be rapidly determined (within 1h) from powders. Thus, the promising materials generated from the foundry (both small molecules and polymers) can rapidly be characterized by this novel electron diffraction technique.

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National Science Foundation

Division of Materials Research

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